LSD1-IN-13 hydrochloride

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
LSD1-IN-13 hydrochloride Basic information
Product Name:LSD1-IN-13 hydrochloride
Synonyms:LSD1-IN-13 hydrochloride
CAS:2170347-90-5
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
LSD1-IN-13 hydrochloride Structure
LSD1-IN-13 hydrochloride Chemical Properties
Safety Information
MSDS Information
LSD1-IN-13 hydrochloride Usage And Synthesis
UsesLSD1-IN-13 hydrochloride (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC50 of 24.43 nM. LSD1-IN-13 hydrochloride can activate CD86 expression, with an EC50 of 470 nM. LSD1-IN-13 hydrochloride induces differentiation of AML (acute myeloid leukemia) cell lines[1].
in vivo

LSD1-IN-13 hydrochloride (compound 7e) (MV-4-11 xenograft mice, 0-20 mg/kg, Orally, daily for 15 days) suppresses tumor growth significantly in a dose-dependent manner[1].

IC 50KDM1/LSD1
References[1] Li C, et al. Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. J Med Chem. 2022 Mar 10;65(5):4335-4349. DOI:10.1021/acs.jmedchem.1c02156
LSD1-IN-13 hydrochloride Preparation Products And Raw materials
Tag:LSD1-IN-13 hydrochloride(2170347-90-5) Related Product Information
1H-Indole-5-carboxamide, 2,3-dihydro-N-[(4-methylphenyl)methyl]-1-[(4-methylphenyl)sulfonyl]- 4-(3,4-dihydroquinolin-1(2H)-ylsulfonyl)aniline(SALTDATA: FREE) 1-[(4-bromophenyl)sulfonyl]-1,2,3,4-tetrahydroquinoline 1-(3-Amino-4-chlorobenzenesulfonyl)-1,2,3,4-tetrahydroquinoline N-(4-(Indolinylsulfonyl)phenyl)ethanamide 1H-Indole, 5-bromo-2,3-dihydro-3-methyl-1-(phenylsulfonyl)-