- Dendrobine
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- $0.00 / 20mg
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2026-02-09
- CAS:2115-91-5
- Min. Order: 20mg
- Purity: ≥98% HPLC
- Supply Ability: 1000kg
- Dendrobine
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- $33.00 / 1mg
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2026-02-03
- CAS:2115-91-5
- Min. Order:
- Purity: 99.70%
- Supply Ability: 10g
- Dendrobine
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- $0.00 / 20mg
-
2023-02-24
- CAS:2115-91-5
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | dendrobine Basic information |
| Product Name: | dendrobine | | Synonyms: | (3α,6α,7R,8S,9R,10α,11α)-Dendrobane-12-one;Dendroban-12-one;12-Oxodendrobane;7,5-(EpoxyMethano)-1H-cyclopent[cd]indol-9-one,decahydro-1,7b-diMethyl-6-(1-Methylethyl)-, (2aS,4aS,5R,6S,7R,7aS,7bR)-;Dendrobine
Dendroban-12-one;Dendrobine 1%;Dendrobine, 98%, from Dendrobium nobile Lindl;Dendrobine 2115-91-5 | | CAS: | 2115-91-5 | | MF: | C16H25NO2 | | MW: | 263.38 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 2115-91-5.mol |  |
| | dendrobine Chemical Properties |
| Melting point | 135-136℃ | | Boiling point | 375℃ | | density | 1.101 | | Fp | 133℃ | | storage temp. | 4°C, protect from light | | solubility | ≥60mg/ml in MeOH | | pka | 9.49±0.60(Predicted) | | form | Powder | | color | White to yellow | | InChI | InChI=1S/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9-,10+,11+,12-,13-,14-,16+/m1/s1 | | InChIKey | RYAHJFGVOCZDEI-UFFNCVEVSA-N | | SMILES | N1(C)[C@@]2([H])[C@]3(C)[C@@]([H])(CC[C@]3([H])C1)[C@@]1([H])C(=O)O[C@]2([H])[C@H]1C(C)C |
| | dendrobine Usage And Synthesis |
| Description | Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity. It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 μg/ml. It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 μg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 μg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin. | | Chemical Properties | It is easily soluble in ether and chloroform, but hardly soluble in ethanol and water. It is an active ingredient extracted from Dendrobium and its bark. | | Uses | Dendrobine is an alkaloid isolated from Dendrobium nobile and is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord. | | Definition | ChEBI: Dendrobine is a member of indoles. | | in vivo | Dendrobine (25 mg/kg, ip for 14 days) exhibits antitumor efficacy in A549 xenograft mouse models[2].
Dendrobine (20 mg/kg, po for 20 days) ameliorates gestational diabetes mellitus (GDM) in mouse models[5]. | Animal Model: | A549 xenograft BALB/c mouse models[2] | | Dosage: | 25 mg/kg | | Administration: | ip for 14 days | | Result: | Inhibited tumor growth. |
| Animal Model: | GDM mouse models[5] | | Dosage: | 20 mg/kg | | Administration: | po for 20 days | | Result: | Improved glucose and insulin tolerance, reduced Th17 cells in the spleen of GDM mice. |
| | References | [1] CHUN-WANG MENG. Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect[J]. Fitoterapia, 2017, 121: Pages 206-211. DOI: 10.1016/j.fitote.2017.07.017
[2] TIAN-HE SONG . Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo[J]. Phytomedicine, 2019, 53: Pages 18-27. DOI: 10.1016/j.phymed.2018.06.018 |
| | dendrobine Preparation Products And Raw materials |
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