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| | scyliorhinin II Basic information |
| Product Name: | scyliorhinin II | | Synonyms: | PubChem ID: 101569057;L-Methioninamide, L-seryl-L-prolyl-L-seryl-L-asparaginyl-L-seryl-L-lysyl-L-cysteinyl-L-prolyl-L-α-aspartylglycyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-valylglycyl-L-leucyl-, cyclic (7→13)-disulfide | | CAS: | 112748-19-3 | | MF: | C77H119N21O26S3 | | MW: | 1851.09 | | EINECS: | | | Product Categories: | | | Mol File: | 112748-19-3.mol |  |
| | scyliorhinin II Chemical Properties |
| Boiling point | 2202.7±65.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 4.01±0.10(Predicted) | | Sequence | Ser-Pro-Ser-Asn-Ser-Lys-Cys-Pro-Asp-Gly-Pro-Asp-Cys-Phe-Val-Gly-Leu-Met-NH2 |
| | scyliorhinin II Usage And Synthesis |
| Uses | Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex. | | in vivo | Scyliorhinin II produces potent, dose-related reciprocal hindlimb scratching about equipotently with an ED50 of 0.08 nmol via intracerebroventricularly (i.c.v.) administration in mice[2]. | | References | [1] Buck SH, et al. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur J Pharmacol. 1987 Nov 24;144(1):109-11. DOI:10.1016/0014-2999(87)90017-3
[2] Raffa RB, et al. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci Lett. 1993 Aug 6;158(1):87-91. DOI:10.1016/0304-3940(93)90619-v |
| | scyliorhinin II Preparation Products And Raw materials |
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