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MedChemexpress LLC
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Product Name:1-Acetyl-3-o-toluyl-5-fluorouracil
CAS:71861-76-2
Purity:200RMB/1mg Package:>98%
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| Company Name: |
Shanghai Han-Xiang Chemical Co., Ltd.
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| Tel: |
15971444841 |
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amber@biochempartner.com |
| Products Intro: |
Product Name:1-Acetyl-3,2-toluyl-5-fluorouracil
CAS:71861-76-2
Purity:98% HPLC LCMS Package:100KG;500KG
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1-acetyl-3,2-toluyl-5-fluorouracil manufacturers
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| | 1-acetyl-3,2-toluyl-5-fluorouracil Basic information |
| Product Name: | 1-acetyl-3,2-toluyl-5-fluorouracil | | Synonyms: | 1-acetyl-3,2-toluyl-5-fluorouracil;1-Acetyl-3-o-toluyl-5-fluorouracil;A-?OT-?Fu;2,4(1H,3H)-Pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-;1 Acetyl 3 o toluyl 5 fluorouracil,1Acetyl3otoluyl5fluorouracil | | CAS: | 71861-76-2 | | MF: | C14H11FN2O4 | | MW: | 290.25 | | EINECS: | | | Product Categories: | | | Mol File: | 71861-76-2.mol |  |
| | 1-acetyl-3,2-toluyl-5-fluorouracil Chemical Properties |
| Melting point | 141-143 °C(Solv: ethyl ether (60-29-7)) | | Boiling point | 408.8±55.0 °C(Predicted) | | density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | -5.29±0.40(Predicted) |
| | 1-acetyl-3,2-toluyl-5-fluorouracil Usage And Synthesis |
| Uses | 1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antitumor agent and a 5-fluorouracil analog. | | in vivo | Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1]. | | References | [1] Yata N, et al. Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration. J Pharmacobiodyn. 1985 Apr;8(4):264-9. DOI:10.1248/bpb1978.8.264 |
| | 1-acetyl-3,2-toluyl-5-fluorouracil Preparation Products And Raw materials |
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