ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
| 中文名称 | ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate |
|---|---|
| 中文同义词 | 1-苄基-3-羟基-2(5H)-氧代吡咯-4-羧酸乙酯;化合物EBPC;EBPC,ALDOSE REDUCTASE抑制剂;化合物EBPC,10 MM DMSO 溶液 |
| 英文名称 | ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate |
| 英文同义词 | 1-Ebpc;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester;Nsc 229530;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;CP-10668;Aldose Reductase,inhibit,EBPC,Inhibitor |
| CAS号 | 4450-98-0 |
| 分子式 | C14H15NO4 |
| 分子量 | 261.27 |
| EINECS号 | |
| 相关类别 | Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals |
| Mol文件 | 4450-98-0.mol |
| 结构式 |  |
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate 性质
| 熔点 | 135-136 °C |
|---|---|
| 沸点 | 479.8±45.0 °C(Predicted) |
| 密度 | 1.340±0.06 g/cm3(Predicted) |
| 储存条件 | room temp |
| 溶解度 | 二甲基亚砜：≥10mg/mL |
| 形态 | 白色粉末 |
| 酸度系数(pKa) | 4.50±1.00(Predicted) |
| 颜色 | white |
| InChI | 1S/C14H15NO4/c1-2-19-14(18)11-9-15(13(17)12(11)16)8-10-6-4-3-5-7-10/h3-7,16H,2,8-9H2,1H3 |
| InChIKey | IGYRPDIWSYGHMY-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1 |
EBPC 是一种有效的选择性醛糖还原酶抑制剂，其 IC50 值为 47 nM。