(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide

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(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide Suppliers list
Company Name: Shanghai Tachizaki Biomedical Research Center  
Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Products Intro: Product Name:PROTAC α-synuclein degrader 3
CAS:2412273-77-7
Purity:98%+HPLC Package:10mg，100mg，500mg，1g，2g，5g+
(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide Basic information
Product Name:(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide
Synonyms:(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide;PROTAC α-synuclein degrader 3
CAS:2412273-77-7
MF:C51H68N6O11S2
MW:1005.25
EINECS:
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Mol File:2412273-77-7.mol
(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide Structure
(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide Chemical Properties
density 1.254±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka13.540±0.46(predicted)
form Solid
color White to light yellow
Safety Information
MSDS Information
(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide Usage And Synthesis
UsesPROTAC α-synuclein degrader 3 (Compound 5) is a selective α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 3 can promote the ubiquitination and degradation of α-synuclein. PROTAC α-synuclein degrader 3 can be used for Parkinson's disease research[1].
IC 50α-synuclein
References[1] Andrew PC, et, al. Proteolysis targeting chimeric (protac) compound with e3 ubiquitin ligase binding activity and targeting alpha-synuclein protein for treating neurodegenerative diseases. WO2020041331A1.
(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide Preparation Products And Raw materials
Tag:(2S,4R)-1-[(S)-2-(tert-Butyl)-23-[[2-[4-(methylamino)phenyl]-6-benzothiazolyl]oxy]-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosan-1-oyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide(2412273-77-7) Related Product Information
dTAGV-1 CC-94676 AU-15330 ARV-825 dBET1 dCBP-1