N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 CAS#: 103141-09-9

N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺

生物活性靶点体外研究体内研究用途与合成方法 MSDS N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺价格(试剂级) 上下游产品信息

中文名称	N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺
中文同义词	N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺;N-(4-甲氧基苯基)-1-苯基-1H-吡唑-3-胺;N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺,10 MM DMSO 溶液
英文名称	FPL 62064
英文同义词	1H-Pyrazol-3-amine,N-(4-methoxyphenyl)-1-phenyl-;FPL 62064;N-(4-Methoxyphenyl)-1-phenyl-1H-pyrazol-3-amine;Cyclooxygenase,FPL 62064,LOX,5-lipoxygenase,FPL62064,inhibit,FPL-62064,Prostaglandin,5-LOX,COX,Inhibitor,synthetase,Lipoxygenase,anti-inflammatory,COX-2;FPL 62064, 10 mM in DMSO
CAS号	103141-09-9
分子式	C16H15N3O
分子量	265.31
EINECS号
相关类别
Mol文件	103141-09-9.mol
结构式

N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺性质

沸点	442.6±25.0 °C(Predicted)
密度	1.15±0.1 g/cm3(Predicted)
储存条件	Keep in dark place,Sealed in dry,Room Temperature
溶解度	二甲基亚砜：250 mg/mL（942.29 mM）
形态	固体
酸度系数(pKa)	2.42±0.50(Predicted)
颜色	浅黄至黄色
化妆品成分功效	ANTI-SEBUM

N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺用途与合成方法

生物活性

FPL 62064 是一种 5-lipoxygenase (5-LOX) 和 prostaglandin synthetase (cyclooxygenase, COX) 的有效双重抑制剂，对RBL-1胞质5-LOX和精囊prostaglandin synthetase的IC50值分别为3.5 μM和3.1 μM。FPL 62064 具有有效的抗炎活性。

靶点

Target	Value
seminal vesicle prostaglandin synthetase (Cell-free assay)	3.1 μM
RBL-1 cytosolic 5-LOX (Cell-free assay)	3.5 μM

体外研究

FPL 62064 inhibits both 5-1ipoxygenase (IC ₅₀ of 3.5 μM for RBL-1 cytosolic 5-1ipoxygenase) and prostaglandin synthetase (IC ₅₀ of 3.1 μM for seminal vesicle prostaglandin synthetase ) with equal facility in the isolated enzyme screens. However in the intact RBL-I cell prostaglandin synthetase (IC ₅₀ of 3.6 μM) is more readily inhibited by FPL 62064 than is 5-1ipoxygenase (IC ₅₀ of 31 μM). This difference in sensitivity is not reflected in the mouse macrophage where the IC ₅₀ s for leukotriene (IC ₅₀ of 0.72 μM) and prostaglandin (IC ₅₀ of 0.43 μM) production are similar.

体内研究

FPL 62064 (5-20 mg/kg; intraperitoneal injection; female LACA mice) treatment inhibits peritoneal inflammation induced by immune-complex.

Animal Model:	Female LACA mice (20-30 g) injected with immune complex.
Dosage:	5 mg/kg, 10 mg/kg, 20 mg/kg
Administration:	Intraperitoneal injection
Result:	Produced a dose-related inhibition of dye extravasation, leukotriene C ₄ (LTC ₄ ) and prostaglandin E ₂ (PGE ₂ ) formation.

安全信息

MSDS信息

N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-105024	N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 FPL 62064	103141-09-9	1 mg	571元
2025/12/22	HY-105024	N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺 FPL 62064	103141-09-9	5mg	1500元

N-(4-甲氧苯基)-1-苯基-1H-吡唑-3-胺