BMS453
| 中文名称 | BMS453 |
|---|---|
| 中文同义词 | 化合物BMS 453;BMS 453,合成类维生素A和RARΒ激动剂;化合物BMS 453,10 MM DMSO 溶液;(E)-4-(2-(5,5-二甲基-8-苯基-5,6-二氢萘-2-基)乙烯基)苯甲酸 |
| 英文名称 | BMS453 |
| 英文同义词 | BMS453;4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoicacid;(E)-4-[2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid;BMS-189453 (BMS189453;(E)-4-[2-(5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)vinyl]benzoic acid;Benzoic acid, 4-[(1E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-;Inhibitor,BMS453,retinoid,RAR/RXR,inhibit,BMS-453,BMS 189453,TGFβ,breast,RARβ,RARγ,Retinoid X receptors,BMS189453,arrest,cell,RARα,Retinoic acid receptors;BMS453, 10 mM in DMSO |
| CAS号 | 166977-43-1 |
| 分子式 | C27H24O2 |
| 分子量 | 380.48 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 166977-43-1.mol |
| 结构式 |  |
BMS453 性质
| 沸点 | 560.9±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.167±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：可溶10mg/mL，澄清 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 4.27±0.10(Predicted) |
| 颜色 | 白色至米色 |
| InChI | 1S/C27H24O2/c1-27(2)17-16-23(21-6-4-3-5-7-21)24-18-20(12-15-25(24)27)9-8-19-10-13-22(14-11-19)26(28)29/h3-16,18H,17H2,1-2H3,(H,28,29)/b9-8+ |
| InChIKey | VUODRPPTYLBGFM-CMDGGOBGSA-N |
| SMILES | OC(C(C=C1)=CC=C1/C=C/C(C=C2)=CC3=C2C(C)(C)CC=C3C4=CC=CC=C4)=O |
BMS453 (BMS-189453) 是一种合成类维生素 A，是一种 RARβ 激动剂和 RARα/RARγ 拮抗剂。BMS453 主要通过诱导活性 TGFβ 来抑制乳腺细胞生长。
BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis.
BMS453 (1 μM; 5 days; 184 and HMEC cells) treatment inhibits normal breast cell proliferation by causing G1 arrest.
BMS453 (1 μM; 24-72 hours; 184 cells) treatment induces Rb hypophosphorylation and decrease CDK2 kinase activity. BMS453 increases total p21 protein levels and CDK2-bound p21 protein, but does not change CDK4-bound p21.
BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ.
Cell Proliferation Assay
| Cell Line: | Normal human mammary epithelial cells (184 and HMEC) |
| Concentration: | 1 μM |
| Incubation Time: | 11 hours |
| Result: | Inhibited 3 H-thymidine uptake in normal breast cells (184 and HMEC) by 40 %. |
Cell Cycle Analysis
| Cell Line: | Normal human mammary epithelial cells (184 and HMEC) |
| Concentration: | 1 μM |
| Incubation Time: | 5 days |
| Result: | Increased the proportion of cells in G0/G1 phase and decreased the proportion of cells in S phase. |
Western Blot Analysis
| Cell Line: | 184 cells |
| Concentration: | 1 μM |
| Incubation Time: | 24 hours, 48 hours, 72 hours |
| Result: | Induced Rb hypophosphorylation and decrease CDK2 kinase activity. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100608 | BMS453 | 166977-43-1 | 1 mg | 359元 |
| 2026/06/05 | HY-100608 | BMS453 BMS453 | 166977-43-1 | 5mg | 848元 |