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| | Eliglustat - D15 Basic information |
| Product Name: | Eliglustat - D15 | | Synonyms: | Octanamide-2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-d15, N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]- | | CAS: | 1628700-80-0 | | MF: | C23H21D15N2O4 | | MW: | 419.64 | | EINECS: | | | Product Categories: | | | Mol File: | 1628700-80-0.mol |  |
| | Eliglustat - D15 Chemical Properties |
| Boiling point | 615.547±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.123±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 13.452±0.20(predicted) |
| | Eliglustat - D15 Usage And Synthesis |
| Uses | Eliglustat-d15 (Genz 99067-d15) is deuterium labeled Eliglustat. Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM[1]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91(3):259-68. DOI:10.1016/j.ijid.2007.01.013 |
| | Eliglustat - D15 Preparation Products And Raw materials |
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