AKE-72 manufacturers
- AKE-72
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- $95.00
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2026-07-27
- CAS:2566525-18-4
- Purity: 99.91%
- Supply Ability: 10g
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| Product Name: | AKE-72 | | Synonyms: | AKE-72;Benzamide, 3-[2-(3-amino-1H-indazol-4-yl)ethynyl]-N-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-;3-((3-Amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide | | CAS: | 2566525-18-4 | | MF: | C30H29F3N6O | | MW: | 546.59 | | EINECS: | | | Product Categories: | | | Mol File: | 2566525-18-4.mol |  |
| | AKE-72 Chemical Properties |
| Boiling point | 659.177±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.394±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 12.503±0.70(predicted) | | color | Off-white to light yellow |
| | AKE-72 Usage And Synthesis |
| Uses | AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 inhibits BCR-ABLWT, BCR-ABLT315, BCR-ABLE255K, BCR-ABLF3171, BCR-ABLH396P and BCR-ABLQ252H with IC50s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line[1]. | | References | [1] 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2228515. DOI:10.1080/14756366.2023.2228515 |
| | AKE-72 Preparation Products And Raw materials |
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