| Company Name: |
Chemphora life sciences
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| Tel: |
+91-9849979989 |
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info@chemphora.com |
| Products Intro: |
Product Name:Boronic acid, B-(2-chloro-4-pyrimidinyl)-
CAS:1228431-85-3
Purity:98% Package:1 kg,5 kg, 10 kg,25kg and 1 MT
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| Company Name: |
SynAsst Chemical.
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| Tel: |
021-60343070 |
| Email: |
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| Products Intro: |
Product Name:2-ChloropyriMidine-4-boronic acid
CAS:1228431-85-3
Purity:96%Min Package:10g 100g 500g
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| Company Name: |
Shanghai JONLN Reagent Co., Ltd.
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| Tel: |
400-0066400 13621662912 |
| Email: |
422131432@qq.com |
| Products Intro: |
Product Name:2-Chloropyrimidine-4-boronicacid
CAS:1228431-85-3
Purity:98% GC Package:1g
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| Company Name: |
Hangzhou Milestone Pharmtech Co., Ltd.
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| Tel: |
0571-82896630 18969958410 |
| Email: |
sales_hz@milestonepharmtech.com |
| Products Intro: |
Product Name:2-bromopyrimidin-4-ylboronic acid pinacol ester
CAS:1228431-85-3
Purity:95% Package:50G
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| Product Name: | 2-Chloropyrimidine-4-boronicacid | | Synonyms: | 2-Chloropyrimidine-4-boronicacid;Boronic acid, B-(2-chloro-4-pyrimidinyl)-;(2-Chloro-4-pyrimidinyl)boronic acid;B-(2-Chloro-4-pyrimidinyl)boronic Acid;(2-ChloropyriMidin-4-yl)boronic acid | | CAS: | 1228431-85-3 | | MF: | C4H4BClN2O2 | | MW: | 158.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1228431-85-3.mol |  |
| | 2-Chloropyrimidine-4-boronicacid Chemical Properties |
| Boiling point | 425.4±37.0 °C(Predicted) | | density | 1.52±0.1 g/cm3(Predicted) | | pka | 5.83±0.53(Predicted) |
| | 2-Chloropyrimidine-4-boronicacid Usage And Synthesis |
| Uses | 2-Chloropyrimidine-4-boronic acid is an organic intermediate commonly used in metal coupling reactions such as the Suzuki reaction. Literature reports that 2-chloropyrimidine-4-boronic acid can be used to synthesize EGFR and ERK kinase inhibitors. EGFR is a member of the erbB (type I) subfamily of RTKs, along with erbB-2, erbB-3, and erbB-4. These receptors are activated by ligands that induce dimerization of their receptors. While EGFR-EGFR homodimers are commonly used for signal transduction, a more common process in this family is ligand-induced heterodimerization, resulting in a signal transduction entity such as EGFR:erbB-2 or erb-B2:erbB-3 with an appropriate ligand. | | Application | 2-Chloropyrimidine-4-boronic acid can be used to synthesize the EGFR kinase inhibitor intermediate 2-chloro-4-(1-methylimidazo[1,5-a]pyridin-3-yl)pyrimidine. |
| | 2-Chloropyrimidine-4-boronicacid Preparation Products And Raw materials |
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