|
|
| | L-Histidine, L-threonyl-L-tryptophyl-L-prolyl-L-lysyl-L-histidyl-L-phenylalanyl-L-α-aspartyl-L-lysyl-L-histidyl-L-threonyl-L-phenylalanyl-L-tyrosyl-L-seryl-L-isoleucyl-L-leucyl-L-lysyl-L-leucylglycyl-L-lysyl- Basic information |
| | L-Histidine, L-threonyl-L-tryptophyl-L-prolyl-L-lysyl-L-histidyl-L-phenylalanyl-L-α-aspartyl-L-lysyl-L-histidyl-L-threonyl-L-phenylalanyl-L-tyrosyl-L-seryl-L-isoleucyl-L-leucyl-L-lysyl-L-leucylglycyl-L-lysyl- Chemical Properties |
| density | 1.319±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | Sequence | Thr-Trp-Pro-Lys-His-Phe-Asp-Lys-His-Thr-Phe-Tyr-Ser-Ile-Leu-Lys-Leu-Gly-Lys-His |
| | L-Histidine, L-threonyl-L-tryptophyl-L-prolyl-L-lysyl-L-histidyl-L-phenylalanyl-L-α-aspartyl-L-lysyl-L-histidyl-L-threonyl-L-phenylalanyl-L-tyrosyl-L-seryl-L-isoleucyl-L-leucyl-L-lysyl-L-leucylglycyl-L-lysyl- Usage And Synthesis |
| Uses | L57 exhibits high affinity to the low-density lipoprotein receptor-related protein 1 (LRP1) with Ki of 45 nM. L57 exhibits blood-brain barrier (BBB) permeability and plasma stability. L57 can be utilized as the carrier for CNS drug delivery[1]. | | References | [1] Sakamoto K, et al., A novel LRP1-binding peptide L57 that crosses the blood brain barrier. Biochem Biophys Rep. 2017 Aug 12;12:135-139. DOI:10.1016/j.bbrep.2017.07.003 |
| | L-Histidine, L-threonyl-L-tryptophyl-L-prolyl-L-lysyl-L-histidyl-L-phenylalanyl-L-α-aspartyl-L-lysyl-L-histidyl-L-threonyl-L-phenylalanyl-L-tyrosyl-L-seryl-L-isoleucyl-L-leucyl-L-lysyl-L-leucylglycyl-L-lysyl- Preparation Products And Raw materials |
|