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| | H-ACH-OMe Basic information |
| Product Name: | H-ACH-OMe | | Synonyms: | 1-Amino-1-cyclohexanecarboxylic acid methyl ester hydrochloride;Methyl 1-aminocyclohexanecarboxylate HYDROCHLORIDE Salt;Methyl 1-Aminocyclohexanecarboxylate HCl;1-Aminocyclohexanecarboxylic acid methyl ester hydrochloride;methyl 1-aminocyclohexane-1-carboxylate hydrochloride;H-ACH-OMe | | CAS: | 37993-32-1 | | MF: | C8H16ClNO2 | | MW: | 193.67114 | | EINECS: | | | Product Categories: | | | Mol File: | 37993-32-1.mol |  |
| | H-ACH-OMe Chemical Properties |
| Melting point | 210-212 °C(Solv: methanol (67-56-1); ethyl ether (60-29-7)) | | storage temp. | Inert atmosphere,Room Temperature | | Appearance | White to off-white Solid |
| | H-ACH-OMe Usage And Synthesis |
| Synthesis | 3.3 Synthesis of methyl 1-aminocyclohexanecarboxylate hydrochloride
To a 20 mL methanol suspension containing 2 g (14 mmol) of 1-aminocyclohexanecarboxylic acid, hydrogen chloride gas was passed for 2 min. Subsequently, 1.2 mL (16.8 mmol) of thionyl chloride was slowly added to the resulting solution and the reaction mixture was heated to reflux for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in 5 mL of methanol, and then 50 mL of ether was slowly added to this solution to induce precipitation of the product. Ultimately, 2.3 g of methyl 1-aminocyclohexanecarboxylate hydrochloride in white powder form was obtained in 85% yield. | | References | [1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
[2] Patent: US2011/9426, 2011, A1. Location in patent: Page/Page column 13
[3] Patent: WO2013/19091, 2013, A2. Location in patent: Paragraph 881-883
[4] Patent: US2014/206875, 2014, A1. Location in patent: Paragraph 0482-0484
[5] Journal of Medicinal Chemistry, 1984, vol. 27, # 12, p. 1663 - 1668 |
| | H-ACH-OMe Preparation Products And Raw materials |
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