N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE manufacturers
|
| | N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Basic information |
| | N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Chemical Properties |
| storage temp. | -10 to -25°C | | solubility | PBS (pH 7.2): Soluble: =10 mg/ml | | form | Solid | | color | White to off-white | | Water Solubility | Soluble to 100 mM in water |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Usage And Synthesis |
| Uses | N1,N11-Diethylnorspermine Tetrahydrochloride is a polyamine analog binding to human serum albumin induce conformational transition and secondary structure change, a partial protein unfolding. | | Biological Activity | DENSPM HCl is a nontoxic polyamine analog th at enhances polyamine catabolism and production of hazardous hydrogen peroxide and N-acetyl-3-aminopropanal by inducing spermidine/spermine-N1-acetyl transferase (SSAT) expression. DENSPM HCl improves stem cell maintenance through reduced translation, exhibits slower proliferation rates in cancer cells, and induces autophagy. It shows greater antitumor activity and less associated toxicity in a human melanoma xenograft model. | | in vivo | N1,N11-Diethylnorspermine (40 mg/kg, three times per day for two cycles of 6 days) tetrahydrochloride clearly prevents tumor growth in mice bearing xenografts of the DU-145 cell line[1].
N1,N11-Diethylnorspermine (120-360 mg/kg, s.c., 4 days) tetrahydrochloride results in prolonged inhibition of tumor growth and long-term tumor regressions in nude athymic mice with MALME-3M melanoma xenografts[5].
N1,N11-Diethylnorspermine (12.5-50 mg/kg, i.v., 5 days) tetrahydrochloride is well tolerated and induces no physical signs in CD rats[6].
| | IC 50 | Caspase 3 | | storage | Store at RT | | References | [1] R G SCHIPPER. Antitumor activity of the polyamine analog N(1), N(11)-diethylnorspermine against human prostate carcinoma cells.[J]. Prostate, 2000, 44 4: 313-321. DOI: 10.1002/1097-0045(20000901)44:4<313::aid-pros8>3.0.co;2-d
[2] R. JIANG. Activation of polyamine catabolism by N1,N11-diethylnorspermine leads to cell death in glioblastoma.[J]. International journal of oncology, 2007, 31 2 1: 431-440. DOI: 10.3892/ijo.31.2.431 |
| | N,N''-BIS[3-(ETHYLAMINO)PROPYL]PROPANE-1,3-DIAMINE TETRAHYDROCHLORIDE Preparation Products And Raw materials |
|