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| | 4,6-PYRIMIDINE DICARBOXYLIC ACID Basic information |
| | 4,6-PYRIMIDINE DICARBOXYLIC ACID Chemical Properties |
| Melting point | 238-240℃ | | Boiling point | 497.4±30.0 °C(Predicted) | | density | 1.665±0.06 g/cm3 (20 ºC 760 Torr) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 2.14±0.10(Predicted) | | form | solid | | color | White |
| | 4,6-PYRIMIDINE DICARBOXYLIC ACID Usage And Synthesis |
| Uses | 4,6-Pyrimidinedicarboxylic Acid is used in the preparation of inhibitor scaffolds that inhibit the human 2-oxoglutarate-dependent JMJD2 subfamily of histone demethylases. | | Synthesis | General procedure for the synthesis of pyrimidine-4,6-dicarboxylic acid from dimethyl pyrimidine-4,6-dicarboxylate: To a solution of dimethyl pyrimidine-4,6-dicarboxylate (170 mg, 0.87 mmol) in methanol (5 mL) was added 1 N sodium hydroxide solution (5 mL, 5.00 mmol). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by evaporation and the resulting concentrated solution was acidified to pH 2-3 with 5 N hydrochloric acid.The resulting white precipitate was collected by filtration and washed with distilled water (2 mL) to give the final pyrimidine-4,6-dicarboxylic acid (125 mg, 86% yield). | | References | [1] Journal of Medicinal Chemistry, 2008, vol. 51, # 22, p. 7053 - 7056
[2] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 77 |
| | 4,6-PYRIMIDINE DICARBOXYLIC ACID Preparation Products And Raw materials |
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