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| | Marbofloxacin-d8 (hydrochloride) Basic information |
| | Marbofloxacin-d8 (hydrochloride) Chemical Properties |
| solubility | DMSO: soluble
Methanol:
Water: (1:1): soluble |
| | Marbofloxacin-d8 (hydrochloride) Usage And Synthesis |
| Description | Marbofloxacin-d8 is intended for use as an internal standard for the quantification of marbofloxacin (Item No. 24174) by GC- or LC-MS. Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml).1 It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 µg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively.2 Intramuscular administration of marbofloxacin (2 mg/kg) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia.3 Oral administration of marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%.4 Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.WARNING This product is not for human or veterinary use. | | References | [1] AUDE A. FERRAN Alain B M Pierre Louis Toutain. Impact of early versus later fluoroquinolone treatment on the clinical; microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infection[J]. Veterinary microbiology, 2011, 148 2: Pages 292-297. DOI: 10.1016/j.vetmic.2010.09.005
[2] M. SPRENG. Antibacterial activity of marbofloxacin. A new fluoroquinolone for veterinary use against canine and feline isolates[J]. Journal of veterinary pharmacology and therapeutics, 1995, 18 4: 284-289. DOI: 10.1111/j.1365-2885.1995.tb00592.x
[3] G. LHERMIE. Impact of Timing and Dosage of a Fluoroquinolone Treatment on the Microbiological, Pathological, and Clinical Outcomes of Calves Challenged with Mannheimia haemolytica[J]. Frontiers in Microbiology, 2016, 7 1. DOI: 10.3389/fmicb.2016.00237
[4] CARMEN PINEDA. Treatment of canine leishmaniasis with marbofloxacin in dogs with renal disease.[J]. PLoS ONE, 2017: e0185981. DOI: 10.1371/journal.pone.0185981 |
| | Marbofloxacin-d8 (hydrochloride) Preparation Products And Raw materials |
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