3-bromo-1H-indazole-7-carbonitrile

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3-bromo-1H-indazole-7-carbonitrile manufacturers

  • iNOS-IN-14
  • iNOS-IN-14 pictures
  • $29.00
  • 2026-07-27
  • CAS:945762-00-5
  • Purity: 99.68%
  • Supply Ability: 10g
3-bromo-1H-indazole-7-carbonitrile Basic information
Product Name:3-bromo-1H-indazole-7-carbonitrile
Synonyms:3-bromo-1H-indazole-7-carbonitrile;1H-INDAZOLE-7-CARBONITRILE, 3-BROMO-;3-bromo-7-cyano-1H-indazole;INOS-IN-14;nNOS-IN-1;3-Bromoindazole-7-carbonitrile
CAS:945762-00-5
MF:C8H4BrN3
MW:222.04
EINECS:
Product Categories:
Mol File:945762-00-5.mol
3-bromo-1H-indazole-7-carbonitrile Structure
3-bromo-1H-indazole-7-carbonitrile Chemical Properties
Boiling point 425.3±25.0 °C(Predicted)
density 1.85±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka8.69±0.40(Predicted)
form Solid
color Off-white to light brown
Safety Information
MSDS Information
3-bromo-1H-indazole-7-carbonitrile Usage And Synthesis
UsesnNOS-IN-1(Compound 14) is an inhibitor for nitric oxide synthases (NOS), that exhibits inhibitory activities against neuroal, inducible and endothelial NOS, with IC50s of 2.5, 5.7 and 13 μM, respectively[1].
IC 50nNOS: 2.5 μM (IC50); iNOS: 5.7 μM (IC50); eNOS: 13 μM (IC50)
References[1] Cottyn B, et al., Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem. 2008 Jun 1;16(11):5962-73. DOI:10.1016/j.bmc.2008.04.056
3-bromo-1H-indazole-7-carbonitrile Preparation Products And Raw materials
Raw materials1H-Indazole, 3-bromo-7-iodo--->1H-Indazole-7-carbonitrile-->ZINC CYANIDE
Tag:3-bromo-1H-indazole-7-carbonitrile(945762-00-5) Related Product Information
1H-Indazole-7-carboxylic acid, 3-bromo- 3-Bromo-7-methyl (1H)indazole 3-Bromo-5-cyano (1H)indazole 3-BroMo-6-cyano (1H)indazole 1H-Indazole-7-carboxamide, 3-bromo- 3-Bromo-1H-indazole-7-carbaldehyde