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| | 3-azabicyclo[3.1.0]hexane Basic information |
| | 3-azabicyclo[3.1.0]hexane Chemical Properties |
| | 3-azabicyclo[3.1.0]hexane Usage And Synthesis |
| Uses |
3-Azabicyclo[3.1.0]hexane is a key structural feature found in a wide range of biologically active natural products, drugs, and agrochemicals.
| | Synthesis | 3-azabicyclo[3.1.0]hexane synthesis: 1-Chlorocyclopropyl p-tolyl sulfoxides with an N,N-disubstituted aminomethyl group on the cyclopropane ring were prepared from dichloromethyl p-tolyl sulfoxide, α,β-unsaturated carboxylic acid esters, primary amines, and alkyl halides. Treatment of the sulfoxides with i-PrMgCl generated cyclopropylmagnesium carbenoids, which were inserted into an intramolecular C–H bond adjacent to a nitrogen atom to give 3-azabicyclo[3.1.0]hexane in yields of up to 94%. |
| | 3-azabicyclo[3.1.0]hexane Preparation Products And Raw materials |
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