- rac-Sitagliptin
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- $2.00
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2026-08-25
- CAS:823817-56-7
- Min. Order: 1KG
- Purity: 99%
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| | rac-Sitagliptin Basic information |
| Product Name: | rac-Sitagliptin | | Synonyms: | 7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine;7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine;rac-SitagliptinSee: S491000;3-AMino-1-[3-(trifluoroMethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone;7-[1-Oxo-3-amino-4-(2,4,5-trifluorophenyl)butyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine;3-aMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;rac-Sitagliptin;1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)- | | CAS: | 823817-56-7 | | MF: | C16H15F6N5O | | MW: | 407.31 | | EINECS: | | | Product Categories: | All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Bases & Related Reagents;Nucleotides | | Mol File: | 823817-56-7.mol |  |
| | rac-Sitagliptin Chemical Properties |
| Boiling point | 529.9±60.0 °C(Predicted) | | density | 1.61±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | DMSO, Ethyl Acetate, Methanol | | pka | 7.20±0.10(Predicted) | | form | Oil | | color | Yellow to Light Brown |
| | rac-Sitagliptin Usage And Synthesis |
| Chemical Properties | Light Brown Syrup | | Uses | A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes. | | in vivo | In vivo, the ED50 value of sitagliptin phosphate for inhibition of plasma DPP-4 activity is calculated to be 2.3 mg/kg 7 hour postdose and 30 mg/kg 24 hour postdose in freely fed Han-Wistar rats[1].The streptozotocin-induced type 1 diabetes mouse model exhibits elevated DPP-4 levels in the plasma that can be substantially inhibited in mice on an Sitagliptin phosphate diet. This is achieved by a positive effect on the regulation of hyperglycemia, potentially through prolongation of islet graft survival[4].The plasma clearance and volume of distribution of Sitagliptin phosphate are higher in rats (40-48 mL/min/kg, 7-9 L/kg) than in dogs (9 mL/min/kg, 3 L/kg); and its half-life is shorter in rats,2 hours compared with 4 hours in dogs[5]. |
| | rac-Sitagliptin Preparation Products And Raw materials |
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