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| | GABAA Receptor β1 Subunit Polyclonal Antibody Basic information |
| | GABAA Receptor β1 Subunit Polyclonal Antibody Chemical Properties |
| | GABAA Receptor β1 Subunit Polyclonal Antibody Usage And Synthesis |
| Description | GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS.1,2 They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: α1-6, β1-4, γ1-3, δ, ε, π, θ, and ρ1-3, arranged around a central pore. Phasic inhibitory synaptic transmission is regulated by α1β2γ2 subunit-containing GABAA receptors, the major isoform found in the brain.2,3 The β subunit of GABAA receptors interfaces with an α subunit to form the GABA binding site that initiates GABA-induced action potentials and forms the benzodiazepine binding site with the γ subunit. Phosphorylation of the β1 subunit by PKA or PKC inhibits binding of the β1 subunit with the clathrin adaptor protein AP2 and reduces GABAA receptor endocytosis.4 Mice expressing mutations in Gabrb1, which encodes the β1 subunit isoform, have increased GABAA receptor-mediated tonic inhibition in the nucleus accumbens and increased alcohol consumption compared to wild-type mice.5 SNPs in GABRB1 are associated with increased impulsivity and reward sensitivity in human adolescents.6 Cayman's GABAA Receptor β1 Polyclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes the GABAA receptor β1 subunit at approximately 55 kDa from mouse and rat samples.WARNING This product is not for human or veterinary use. |
| | GABAA Receptor β1 Subunit Polyclonal Antibody Preparation Products And Raw materials |
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