4-Methyl-2-oxovaleric acid manufacturers
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| | 4-Methyl-2-oxovaleric acid Basic information |
| Product Name: | 4-Methyl-2-oxovaleric acid | | Synonyms: | ALPHA-KETOISOCAPROIC ACID;4-METHYL-2-OXOPENTANOIC ACID;4-METHYL-2-OXOVALERIC ACID;4-Methyl-2-oxovaleric acid >=98.0% (T);Methyl-2-oxovaleric;KETOLEUCINE;2-KETO-ISO-CAPROIC ACID;2-keto-isocaproate | | CAS: | 816-66-0 | | MF: | C6H10O3 | | MW: | 130.14 | | EINECS: | 212-435-5 | | Product Categories: | | | Mol File: | 816-66-0.mol |  |
| | 4-Methyl-2-oxovaleric acid Chemical Properties |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3265 8/PG 3 | | WGK Germany | 3 | | F | 3-9-13 | | TSCA | TSCA listed | | HS Code | 2918.30.9000 | | HazardClass | 8 | | PackingGroup | III | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | 4-Methyl-2-oxovaleric acid Usage And Synthesis |
| Occurrence | Reported found in banana, asparagus, cheese, white wine, cocoa, blue cheese and provolone cheese. | | Uses | 4-Methyl-2-oxovaleric acid is an intermediate in the metabolism of leucine and also used as flavoring agents. | | Definition | ChEBI: A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease. | | in vivo | 4-Methyl-2-oxopentanoic acid (4 mol/L; ICV; 1 h and 15 d) causes impairment of habitual memory and long-term memory in rats[3].
4-Methyl-2-oxopentanoic acid (400 μmol/kg/h; carotid arch injection; single dose injection 60 min) increases porcine skeletal muscle protein synthesis and plasma leucine levels[4]. | Animal Model: | Thirty-day-old rats were anesthetized with a mixture of ketamine and xylazine (HY-B0443)[3] | | Dosage: | 4 mol/L, Administer 2 μL | | Administration: | Intracerebroventricular injection (ICV); 1 h and 15 days | | Result: | Increased TBARS levels, protein carbonyl content and DNA damage in the hippocampus, striatum and cerebral cortex.
SOD activity in the hippocampus and striatum increased 1 hour after injection, and SOD activity in the striatum decreased 15 days later.
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| Animal Model: | Piglets were deprived of feed for 12-14 hours before infusion[4] | | Dosage: | 400 μmol/kg | | Administration: | Inject into the aortic arch; the initial injection dose is 148 μmol/kg in the first 10 minutes, and the continuous infusion dose is 400 μmol/kg | | Result: | Increased phosphorylation of eukaryotic initiation factor (eIF) 4E binding protein-1 (4E-BP1) and eIF4G in skeletal muscle and increased the formation of active eIF4G×eIF4E complexes. |
| | IC 50 | Human Endogenous Metabolite |
| | 4-Methyl-2-oxovaleric acid Preparation Products And Raw materials |
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