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| | LL-37 Monoclonal Antibody (Clone 3G10) Basic information |
| | LL-37 Monoclonal Antibody (Clone 3G10) Chemical Properties |
| | LL-37 Monoclonal Antibody (Clone 3G10) Usage And Synthesis |
| Description | LL-37 is a cationic α-helical peptide expressed in human bone marrow, testis, granulocytes, gingival epithelium, and a variety of immune cells.1 It is produced by proteolytic cleavage of the cathelicidin human cationic antimicrobial protein of 18 kDa (hCAP18).2 LL-37 has antimicrobial and antiviral activity, and protein levels of LL-37 are increased in epithelial cells, macrophages, and neutrophils following bacterial infection in vitro.1,3,4,5 It functions as a chemoattractant for human monocytes, neutrophils, and T cells, and induces chemokine secretion from epithelial cells in infected tissues.6,2 LL-37 is a component of LPS-induced neutrophil extracellular traps (NETs) produced from human neutrophils isolated from patients with systemic lupus erythrematosus (SLE) or individuals without SLE.7 It also enhances formation of NETs induced by phorbol 12-myristate 13-acetate (PMA) or S. aureus.8 LL-37 can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4, a modification that reduces its antibacterial and antiviral activities.9,5 Native, but not citrullinated, LL-37 prevents mortality in a mouse model of D-galactosamine-sensitized endotoxic shock.9 Cayman's LL-37 Monoclonal Antibody (Clone 3G10) can be used for ELISA and flow cytometry (FC) applications.WARNING This product is not for human or veterinary use. |
| | LL-37 Monoclonal Antibody (Clone 3G10) Preparation Products And Raw materials |
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