- Fmoc-L-Gln(Trt)-OH
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- $0.00 / 1kg
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2026-03-12
- CAS:132327-80-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
- Fmoc-L-Gln(Trt)-OH
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- $50.00 / 1kg
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2025-05-23
- CAS:132327-80-1
- Min. Order: 1kg
- Purity: 99
- Supply Ability: 5000
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| | Nalpha-Fmoc-Ndelta-trityl-L-glutamine Basic information |
| | Nalpha-Fmoc-Ndelta-trityl-L-glutamine Chemical Properties |
| Melting point | 165-172 °C | | Boiling point | 873.5±65.0 °C(Predicted) | | density | 1.256±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | pka | 3.73±0.10(Predicted) | | form | Powder | | color | White to yellow | | Optical Rotation | [α]/D -14.0±1.5°, c = 1% in DMF | | Sensitive | Moisture Sensitive | | BRN | 4343953 | | Major Application | peptide synthesis | | InChI | InChI=1S/C39H34N2O5/c40-36(42)25-24-35(37(43)44)41(38(45)46-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34)39(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29/h1-23,34-35H,24-26H2,(H2,40,42)(H,43,44)/t35-/m0/s1 | | InChIKey | WDGICUODAOGOMO-DHUJRADRSA-N | | SMILES | C(O)(=O)[C@H](CCC(N)=O)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1 | | CAS DataBase Reference | 132327-80-1(CAS DataBase Reference) |
| | Nalpha-Fmoc-Ndelta-trityl-L-glutamine Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses |
FMOC-GLN(TRT)-OH, is an amino acid derivative used in chemical synthesis and peptide chemistry.
| | General Description |
Nalpha-Fmoc-Ndelta-trityl-L-glutamine has good solubility properties in most organic solvents, and its use has been shown to result in significantly purer peptides than other derivatives used for the introduction of Gln [1]. Coupling can be performed by standard procedures. The trityl-protecting group is normally removed by 95% TFA in 1-3 hours, with no alkylation of Trp.
| | reaction suitability | reaction type: Fmoc solid-phase peptide synthesis | | Synthesis | At room temperature, 9- BBN-protected glutamine ( 1 mmol) was stirred vigorously in acetonitrile ( 2 mL), then disodium hydrogen phosphate ( 3 mmol , 426 mg) was added to the resulting reaction solution, and trifluoroperoxyacetic acid ( 6 mL , 0.5 M in CH3CN) was added dropwise to the reaction mixture. The progress of the reaction was determined by TLC and the reaction mixture was allowed to stir until the ingredients were consumed. The reaction was quenched by addition of 20 % Na2SO3 aqueous solution ( 1 m L ). The solvent was removed on a rotary evaporator and the resulting residue was dissolved with dioxane ( 15 mL) and water ( 5 mL) and then treated with solid NaHCO3 ( 5 mmol , 420 mg). The resulting solution was cooled to 0 C and 9-fluorenylmethyl-N-succinimidyl carbonate was added to it. The resulting reaction mixture was stirred at a water ice bath temperature for 30 min. the reaction was stirred until the amino acid was completely converted and the volatiles were removed. A further 20 mL of water was added to the reaction solution and the p H of the reaction system was adjusted with 1 M KHSO4 to 3. The aqueous phase was extracted three times with dichloromethane ( 4 15 mL), and the combined organic extracts were dried with anhydrous Na2SO4, filtered to remove the desiccant and the resulting mixture of organic extracts was concentrated under vacuum. The residue was purified by silica gel column chromatography using dichloromethane/methanol/formic acid (0.1 %) as eluent to give the target product molecule. |
| | Nalpha-Fmoc-Ndelta-trityl-L-glutamine Preparation Products And Raw materials |
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