Imidazo[1,2-a]pyridine, 7-bromo-

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Imidazo[1,2-a]pyridine, 7-bromo- manufacturers
Imidazo[1,2-a]pyridine, 7-bromo- Basic information
Product Name:Imidazo[1,2-a]pyridine, 7-bromo-
Synonyms:7-bromoH-imidazo[1,2-a]pyridine hydrochloride;7-Bromoimidazo[1,2-a]pyri...;7-broMoH-iMidazo[1,2-a]pyridine;7-bromoimidazo[1,2-a]pyridine HCL;7-Bromoimidazo[1,2-a]pyridine;Imidazo[1,2-a]pyridine, 7-bromo-
CAS:808744-34-5
MF:C7H5BrN2
MW:197.03
EINECS:1533716-785-6
Product Categories:
Mol File:808744-34-5.mol
Imidazo[1,2-a]pyridine, 7-bromo- Structure
Imidazo[1,2-a]pyridine, 7-bromo- Chemical Properties
Melting point 118-120℃
density 1.69
storage temp. Sealed in dry,Room Temperature
form solid
pka5.15±0.50(Predicted)
color White to off-white
InChIInChI=1S/C7H5BrN2/c8-6-1-3-10-4-2-9-7(10)5-6/h1-5H
InChIKeyOASOJRLJBDCVNU-UHFFFAOYSA-N
SMILESC12=NC=CN1C=CC(Br)=C2
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
HS Code 2933599590
Storage Class11 - Combustible Solids
MSDS Information
Imidazo[1,2-a]pyridine, 7-bromo- Usage And Synthesis
Synthesis
Chloroacetaldehyde

107-20-0

2-Amino-4-bromopyridine

84249-14-9

IMIDAZO[1,2-A]PYRIDINE, 7-BROMO-

808744-34-5

2-Amino-4-bromopyridine (5.0 g) and 2-chloroacetaldehyde (40% aqueous, 12 mL, 2.5 eq.) were dissolved in anhydrous ethanol (50 mL) and sodium bicarbonate (4.89 g, 2.0 eq.) was added. The reaction mixture was heated to reflux for 6 hours. Upon completion of the reaction, the organic solvent was removed by vacuum rotary evaporation. The residue was extracted with ethyl acetate (60 mL) and washed sequentially with water and saturated saline. The organic layer was dried with anhydrous sodium sulfate, filtered and purified by silica gel column chromatography to afford 7-bromoimidazo[1,2-a]pyridine (4.38 g, 78% yield) as a brown solid.

References[1] Patent: CN106496222, 2017, A. Location in patent: Paragraph 0095; 0097
[2] Patent: WO2008/124323, 2008, A1. Location in patent: Page/Page column 68
[3] Patent: WO2008/121687, 2008, A2. Location in patent: Page/Page column 53
[4] Patent: WO2017/144633, 2017, A1. Location in patent: Page/Page column 101; 102
[5] Patent: WO2017/144639, 2017, A1. Location in patent: Page/Page column 87
Imidazo[1,2-a]pyridine, 7-bromo- Preparation Products And Raw materials
Raw materialsChloroacetaldehyde-->2-Amino-4-bromopyridine-->Ethanol-->Sodium bicarbonate
Tag:Imidazo[1,2-a]pyridine, 7-bromo-(808744-34-5) Related Product Information
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