- Omeprazole Impurity 25
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- $0.00 / 10mg
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2026-01-23
- CAS:119141-89-8
- Min. Order: 10mg
- Purity: 0.98
- Supply Ability: 10g
- OMEPRAZOLE
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- $1.00 / 1KG
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2019-07-06
- CAS: 119141-89-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000KG
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| | OMEPRAZOLE Basic information |
| Product Name: | OMEPRAZOLE | | Synonyms: | ZOLTUM;6-methoxy-2-[(R)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole;Omeprazole Impurity N;R-Omeparazole;Esomeprazole Sodium Impurity 15;Omeprazole Impurity 33;omeprazole impurity B (r-omeprazole);Omeprazole impurity 18/(R)-Omeprazole/(R)-5-Methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole | | CAS: | 119141-89-8 | | MF: | C17H19N3O3S | | MW: | 345.42 | | EINECS: | 201-212-8 | | Product Categories: | Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 119141-89-8.mol |  |
| | OMEPRAZOLE Chemical Properties |
| Melting point | >47°C (dec.) | | Boiling point | 600.0±60.0 °C(Predicted) | | density | 1.37±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | Sealed in dry,Room Temperature | | solubility | H2O: 0.5 mg/mL | | form | solid | | pka | 8.78±0.10(Predicted) | | color | white | | Stability: | Hygroscopic | | InChI | InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)/t24-/m1/s1 | | InChIKey | SUBDBMMJDZJVOS-XMMPIXPASA-N | | SMILES | C1([S@@](CC2=NC=C(C)C(OC)=C2C)=O)NC2=CC(OC)=CC=C2N=1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 2 | | RTECS | DD9087000 |
| | OMEPRAZOLE Usage And Synthesis |
| Uses | R-Form of Omeprazole. Gastric proton-pump inhibitor | | Uses | (R)-Omeprazole is the R-enantiomer of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative. | | Definition | ChEBI: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has R configuration at the sulfur atom. | | Synthesis | GENERAL STEPS: Sulfide (5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]benzimidazole, 100 mmol) and titanium-tannic acid catalyst (1.1 mmol) were dissolved in ethyl acetate (EtOAc, 6.0 mL). The reaction mixture was kept at a constant temperature to the indicated temperature (usually 0°C, or in the range of -20 to +20°C for variable temperature experiments). Subsequently, a 30% aqueous hydrogen peroxide solution (0.105 mmol H2O2) was added all at once. The reaction mixture was continuously stirred at 500 rpm at a constant temperature (usually 24 h). For low-temperature experiments, the reaction time was about 30 h at -10 °C, which could be extended to 10 days at -20 °C. To analyze the progress of the reaction, 20 μL of the reaction mixture was taken into a vial and immediately evaporated carefully to dryness (~15-20 s) with a stream of compressed air. The residual solid was dissolved in isopropanol solution (0.20 mL) containing 1% triethylamine (Et3N), and the residual sulfide, (R)- and (S)-sulfoxide, and sulfone contents were analyzed by chiral HPLC. | | References | [1] Catalysis Today, 2017, vol. 279, p. 84 - 89
[2] Heterocyclic Communications, 2016, vol. 22, # 1, p. 17 - 19
[3] Patent: US2008/319195, 2008, A1. Location in patent: Page/Page column 5
[4] Patent: US9228216, 2016, B2. Location in patent: Page/Page column 50-52
[5] Journal of Organic Chemistry, 2018, vol. 83, # 14, p. 7453 - 7458 |
| | OMEPRAZOLE Preparation Products And Raw materials |
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