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| | Trifluoromethanesulfonamide Basic information | | Reaction |
| | Trifluoromethanesulfonamide Chemical Properties |
| Melting point | 120-124 °C(lit.) | | Boiling point | 164.6±45.0 °C(Predicted) | | density | 1.730±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 6.37±0.60(Predicted) | | color | Off-White | | Water Solubility | Soluble in water. | | BRN | 1812099 | | InChI | InChI=1S/CH2F3NO2S/c2-1(3,4)8(5,6)7/h(H2,5,6,7) | | InChIKey | KAKQVSNHTBLJCH-UHFFFAOYSA-N | | SMILES | C(F)(F)(F)S(N)(=O)=O | | CAS DataBase Reference | 421-85-2(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | Hazard Note | Harmful | | HS Code | 29350090 |
| | Trifluoromethanesulfonamide Usage And Synthesis |
| Reaction | Trifluoromethanesulfonamide can react with
paraformaldehyde in sulfuric acid to give open chain and cyclic
condensation products, or in ethyl acetate to give oxy-methylated
products. | | Chemical Properties | White to off-white solid | | Uses | Trifluoromethanesulfonamide is used as an intermediate in synthetic chemistry. It is used in the preparation of specific inhibitors of mammalian secreted phospholipases A2. It is also involved in the synthesis of ecicosanoids. | | Application | It is known that benzylamine-type trifluoromethanesulfonamide
derivatives such as N-benzyltrifluoromethanesulfonamide and the like and
trifluoromethanesulfonamide derivatives having a condensed heterocyclic
ring structure have herbicidal activity so that they are used as a
herbicide. | | Synthesis | 15.39
trifluoromethanesulfonyl chloride dissolved in 103 g of anhydrous
isopropyl ether is charged to a reactor. The medium is cooled to 5 °C.
and the ammonia is added slowly over 2 hours. After 5 hours of stirring
at 5° C., 24.8 g of water are added to dissolve the salts. The medium is
then acidified by adding 20.7 g of a 36% aqueous hydrochloric acid
solution.
After a further addition of 13 g of water, the phases are separated.
The aqueous phase is washed with 50 g of isopropyl ether. The organic
phases are combined and the solvent is removed under reduced pressure.
10.15 g of a white solid of trifluoromethanesulfonamide are thus obtained. |
| | Trifluoromethanesulfonamide Preparation Products And Raw materials |
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