- 4-Aminoisoquinoline
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- $0.00 / 25kg
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2025-12-01
- CAS:23687-25-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 10000KGS
- 4-Isoquinolylamine
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- $1.10 / 1g
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2025-11-18
- CAS:23687-25-4
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
- 4-Isoquinolylamine
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- $8.00 / 1KG
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2019-07-06
- CAS:23687-25-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10tons
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| | 4-Aminoisoquinoline Basic information |
| | 4-Aminoisoquinoline Chemical Properties |
| Melting point | 108.0 to 112.0 °C | | Boiling point | 360.0±17.0 °C(Predicted) | | density | 1.210±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 6.29±0.10(Predicted) | | color | White to Brown | | InChI | InChI=1S/C9H8N2/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H,10H2 | | InChIKey | ISIUXVGHQFJYHM-UHFFFAOYSA-N | | SMILES | C1C2=C(C=CC=C2)C(N)=CN=1 | | CAS DataBase Reference | 23687-25-4(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-36 | | Safety Statements | 26 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2933499090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2 |
| | 4-Aminoisoquinoline Usage And Synthesis |
| Uses | 4-Isoquinolylamine can be used for synthesis of Rho kinase inhibitors. | | Synthesis Reference(s) | Journal of the American Chemical Society, 64, p. 783, 1942 DOI: 10.1021/ja01256a012 | | Synthesis | A mixture of N-benzyl-4-aminoisoquinoline (1.00 g, 4.27 mmol) was reacted with a mixture of acetic acid (30 mL) and H2SO4 (7.5 mL, concentration not specified) for 6 hours at 100 °C with stirring. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with saturated aqueous NaHCO3 solution. Subsequently, Na2CO3 (200 mL) was added and diluted with water, followed by extraction with EtOAc (5 x 25 mL). The organic phases were combined, concentrated and the residue was purified by chromatography (eluent: EtOAc) to afford the target compound 4-aminoisoquinoline (325 mg, 53% yield) as a yellow solid.1H NMR (DMSO-d6, 400 MHz) δ 8.49 (s, 1H), 8.10 (d, 1H), 7.90 (d, 1H), 7.87 (s, 1H ), 7.64-7.54 (m, 2H), 5.82 (s, 2H). | | Solubility in organics | 4-isoquinolamine (4-Aminoisoquinoline) is slightly soluble in water and more soluble in organic solvents such as ethanol, dimethylformamide and dichloromethane.
| | References | [1] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 49 |
| | 4-Aminoisoquinoline Preparation Products And Raw materials |
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