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2,3-Difluorophenol

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CAS:6418-38-8
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  • 2,3-Difluorophenol
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  • 2026-03-20
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  • Purity: 99%
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  • 2,3-Difluorophenol
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  • 2025-09-25
  • CAS:6418-38-8
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  • Purity: 99%
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  • 2,3-Difluorophenol
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  • 2021-07-13
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2,3-Difluorophenol Basic information
Product Name:2,3-Difluorophenol
Synonyms:2,3-DIFLUOROPHENOL;PHENOL, 2,3-DIFLUORO-;2,3-Difluorophenol,98+%;2,3-Difluorophenole;2,3-Difluorophenol 98%;Difluorophenol;2,3-Difluorophenol 6418-38-8 fiona;2,3-Difluorophenol ,99%
CAS:6418-38-8
MF:C6H4F2O
MW:130.09
EINECS:264-750-2
Product Categories:Phenyls & Phenyl-Het;Indolines ,Indoles ,Indazoles;Organic Building Blocks;Oxygen Compounds;Phenols;Fluorine series;Phenyls & Phenyl-Het;Phenol&Thiophenol&Mercaptan;Miscellaneous;Fluorophenols;Aromatic Halides (substituted);Fluorobenzene;Alcohols and Derivatives;Trifluoromethoxybenzene Series;Other fluorin-contained compounds;bc0001
Mol File:6418-38-8.mol
2,3-Difluorophenol Structure
2,3-Difluorophenol Chemical Properties
Melting point 39-42 °C (lit.)
Boiling point 54 °C/25 mmHg (lit.)
density 1.2483 (estimate)
Fp 134 °F
storage temp. Inert atmosphere,2-8°C
pka7.71±0.10(Predicted)
form powder to lump to clear liquid
color White or Colorless to Almost white or Almost colorless
BRN 2082265
InChIInChI=1S/C6H4F2O/c7-4-2-1-3-5(9)6(4)8/h1-3,9H
InChIKeyRPEPGIOVXBBUMJ-UHFFFAOYSA-N
SMILESC1(O)=CC=CC(F)=C1F
CAS DataBase Reference6418-38-8(CAS DataBase Reference)
Safety Information
Hazard Codes F,Xn,Xi,C
Risk Statements 11-22-36/37/38-34-20/21/22
Safety Statements 26-45-36/37/39-16
RIDADR UN 1325 4.1/PG 2
WGK Germany 3
Hazard Note Irritant
HazardClass 4.1
PackingGroup III
HS Code 29081000
Storage Class3 - Flammable liquids
Hazard ClassificationsAcute Tox. 4 Oral
Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
2,3-Difluorophenol Usage And Synthesis
Chemical Propertieswhite crystalline low melting mass
UsesIntermediates of Liquid Crystals
Application2,3-Difluorophenol was used in the synthesis of material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} (PMDFPS) sensitive to toxic organophosphate.
Synthesis
2,3-Difluorophenylboronic acid

121219-16-7

2,3-Difluorophenol

6418-38-8

Step 1: In a 500 mL round-bottomed flask, dissolve 2,3-difluorophenylboronic acid (30 g, 189.98 mmol, 1.00 eq.) in dichloromethane (250 mL). Hydrogen peroxide (30 mL) was added slowly and dropwise under stirring conditions. The reaction mixture was stirred continuously at 25°C for 2 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with water and saturated saline, the organic phase was dried over anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 2,3-difluorophenol 23 g (93% yield) as a brown oil.

References[1] K.P. RAJAPPAN NAIR . Supersonic jet microwave rotational spectrum of 2,3-difluorophenol[J]. Journal of Molecular Structure, 2019, 1195: Pages 479-484. DOI:10.1016/j.molstruc.2019.06.004.
[2] WEI HE . Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coating for DMMP detection[J]. Talanta, 2008, 76 3: Pages 698-702. DOI:10.1016/j.talanta.2008.04.022.
[3] E. MARZI M. S J Gorecka. The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates[J]. Synthesis-Stuttgart, 2004, 441 1: 1609-1618. DOI:10.1055/S-2004-829110.
Tag:2,3-Difluorophenol(6418-38-8) Related Product Information
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