2-Chloro-5-chloromethylthiophene manufacturers
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| | 2-Chloro-5-chloromethylthiophene Basic information |
| | 2-Chloro-5-chloromethylthiophene Chemical Properties |
| Boiling point | 83-85 °C8 mm Hg(lit.) | | density | 1.385 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.575(lit.) | | Fp | 213 °F | | storage temp. | -20°C | | form | Liquid | | color | Colorless to brown | | InChI | 1S/C5H4Cl2S/c6-3-4-1-2-5(7)8-4/h1-2H,3H2 | | InChIKey | MQTKXCOGYOYAMW-UHFFFAOYSA-N | | SMILES | ClCc1ccc(Cl)s1 | | CAS DataBase Reference | 23784-96-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HS Code | 29349990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Chloro-5-chloromethylthiophene Usage And Synthesis |
| Chemical Properties | Clear colorless to yellow liquid | | Uses | 2-Chloro-5-(chloromethyl)thiophene was used in the synthesis of 1-(1,1′-biphenyl-4-yl)-3-(5-chloro-thiophen-2-yl)-2-(1H-imidazol-1-yl)propane and 1-(5-chlorothiophen-2-yl)-2-(1H-imidazol-1-yl)-3-phenylpropane. | | Synthesis | Under nitrogen protection, 5-chloro-2-thiophene methanol (500 mg, 3.37 mmol) was dissolved in tetrahydrofuran (10 mL) and cooled to 0 °C. Subsequently, CN (482 mg, 4.05 mmol) was added dropwise. After the dropwise addition, the reaction mixture was warmed up to 50 °C for 3 h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford 480 mg of 2-chloro-5-chloromethylthiophene in yellow liquid form (yield: 85.5%), which could be used directly in the subsequent reaction without further purification. | | References | [1] Patent: CN107188865, 2017, A. Location in patent: Paragraph 0113; 0116; 0117 |
| | 2-Chloro-5-chloromethylthiophene Preparation Products And Raw materials |
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