6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride

Request For Quotation
6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride Suppliers list
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Email:
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 177-54423994 17754423994
Email: 2853530910@QQ.com

6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride manufacturers

  • CAY10462
  • CAY10462 pictures
  • $29.00
  • 2026-07-15
  • CAS:502656-68-0
  • Purity: 99.88%
  • Supply Ability: 10g
6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride Basic information
Product Name:6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride
Synonyms:CAY10462;6-(4-imidazol-1-ylphenoxy)-N,N-dimethylhexan-1-amine:dihydrochloride;CAY10462 2HCl;CAY 10462 dihydrochloride;6-(4-(1H-Imidazol-1-yl)phenoxy)-N,N-dimethylhexan-1-amine dihydrochloride;6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride
CAS:502656-68-0
MF:C17H27Cl2N3O
MW:360.32
EINECS:
Product Categories:
Mol File:Mol File
6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride Structure
6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride Chemical Properties
solubility DMSO: 15 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid
color Off-white to light yellow
Safety Information
MSDS Information
6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride Usage And Synthesis
Description20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family.1,2 Alkylaryl imidazoles have been shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis.3 CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 of 8.8 nM when tested in human renal microsomes.4 CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.
UsesCAY 10434 dihydrochloride is a potent CYP4A hydroxylase inhibitor. CAY 10434 dihydrochloride improves contractile response to angiotensin II with the maximal contractile response (Emax) 6764 mg[1].
References1. Harder, D.R., Lange, A.R., Gebremedhin, D., et al. Cytochrome P450 metabolites of arachidonic acid as intracellular signaling molecules in vascular tissue J. Vasc. Res. 34,237-243(1997).
2. Imig, J.D., Zou, A.P., Stec, D.E., et al. Formation and actions of 20-hydroxyeicosatetraenoic acid in rat renal arterioles Am. J. Physiol. 270,R217-R227(1996).
3. Nakamura, T., Kakinuma, H., Umemiya, H., et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitor Bioorg. Med. Chem. Lett. 14,333-336(2004).
6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride Preparation Products And Raw materials
Tag:6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride(502656-68-0) Related Product Information
CAY10505 Benzamide, 4-(dimethylamino)-N-[3-[[2-[(4-oxo-4H-1-benzopyran-7-yl)oxy]acetyl]amino]phenyl]- 4-(4-IMIDAZOL-1-YL-PHENOXY)-PIPERIDINE 6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE 4-(4-(1H-Imidazol-1-yl)phenoxy)piperidine dihydrochloride 1-[4-(Cyclohexyloxy)phenyl]-1H-imidazole