Methyl 2-bromo-4-fluorobenzoate

Methyl 2-bromo-4-fluorobenzoate Suppliers list

Company Name:	Shanghai Boke Pharmaceutical Technology Co., Ltd. Gold
Tel:	18367689840
Email:	stella_boke@163.com

Company Name:	Beijing Hezhicheng Chemical Products Co., Ltd Gold
Tel:	18311365218 18311365218
Email:	sales@toachem.com

Company Name:	Shijiazhuang Sdyano Fine Chemical Co., Ltd.
Tel:	0311-89250318 13582355795
Email:	master@sjzsdyn.com

Methyl 2-bromo-4-fluorobenzoate manufacturers

Methyl 2-bromo-4-fluorobenzoate Basic information

Product Name:	Methyl 2-bromo-4-fluorobenzoate
Synonyms:	METHYL 2-BROMO-4-FLUOROBENZOATE;Methyl 2-bromo-4-fluorobenzoate 98%;Methyl2-bromo-4-fluorobenzoate98%;RARECHEM AL BF 1088;methyl 2-bromo-4-fluorobenzenecarboxylate;Methyl 4-fluoro-2-bromobenzoate;5-fluoro-2-(methoxycarbonyl)bromobenzene;Benzoic acid, 2-broMo-4-fluoro-, Methyl ester
CAS:	653-92-9
MF:	C8H6BrFO2
MW:	233.03
EINECS:
Product Categories:	blocks;Bromides;Carboxes;FluoroCompounds
Mol File:	653-92-9.mol

Methyl 2-bromo-4-fluorobenzoate Chemical Properties

Boiling point	75-78/1mm
density	1.577
Fp	100℃
storage temp.	Sealed in dry,Room Temperature
Appearance	Colorless to light yellow Liquid
InChI	InChI=1S/C8H6BrFO2/c1-12-8(11)6-3-2-5(10)4-7(6)9/h2-4H,1H3
InChIKey	JENBPOJAZCPSEW-UHFFFAOYSA-N
SMILES	C(OC)(=O)C1=CC=C(F)C=C1Br

Safety Information

MSDS Information

Methyl 2-bromo-4-fluorobenzoate Usage And Synthesis

Uses	Methyl 2-bromo-4-fluorobenzoate is a carboxylic acid ester derivative used as an organic intermediate.
Chemical Properties	off-white powder
Synthesis	DBU (1.7 equiv, 1.16 mL, 7.76 mmol) was added to a solution of 2-bromo-4-fluorobenzoicacid (1.0equiv, 1.0 g, 4.57 mmol) and iodomethane (2.0 equiv, 0.57 mL, 9.14 mmol) in CH3CN(11 mL) at 23 °C. After stirring for 48 h, the reaction was quenched with H2O(10 mL) and extracted with Et2O (2 x 10 mL). The combined organic extracts were washed with water (20 mL) and brine (20 mL), dried over Na2SO4 and filtrated. Evaporation of the solvent under reduced pressure followed by flash chromatography (SiO2, 95/5 hexane/EtOAc) afforded 1.0 g (98%)of Methyl 2-bromo-4-fluorobenzoate as a colourless oil.
References	[1] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4393 - 4398 [2] Patent: US6407250, 2002, B1 [3] Patent: US6511999, 2003, B2 [4] Patent: US2002/128233, 2002, A1 [5] Patent: US2004/162323, 2004, A1

Methyl 2-bromo-4-fluorobenzoate Preparation Products And Raw materials

Raw materials	Methanol-->2-Bromo-4-fluorobenzoic acid-->Iodomethane-->(Trimethylsilyl)diazomethane-->DBU-->Acetonitrile
Preparation Products	Ethyl4-fluoro-2-formylbenzoate-->Benzenemethanol, 2-ethyl-4-fluoro--->5-Fluoro-2-(methoxycarbonyl)phenylboronic acid pinacol este-->2-(2-bromo-4-fluorophenyl)pyrrolidine

Tag:Methyl 2-bromo-4-fluorobenzoate(653-92-9) Related Product Information

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