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| | 15D-PGJ2 Basic information |
| Product Name: | 15D-PGJ2 | | Synonyms: | 15-deoxy-Δ12,14-Prostaglandin J2 Lipid Maps MS Standard;11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid;15-Deoxy-Δ12,14-PGJ2;15-deoxy-Δ12,14-Prostaglandin J2 solution;15d-PGJ?;15D-PGJ2;15-DEOXY-DELTA12,14-PROSTAGLANGIN J2;15-DEOXY-DELTA12,DELTA14-PROSTAGLANDIN J2 | | CAS: | 87893-55-8 | | MF: | C20H28O3 | | MW: | 316.43 | | EINECS: | 201-185-2 | | Product Categories: | | | Mol File: | 87893-55-8.mol |  |
| | 15D-PGJ2 Chemical Properties |
| Fp | -9℃ | | storage temp. | -20°C | | solubility | Soluble in Methyl acetate (supplied pre-dissolved - 1mg/ml) | | form | methyl acetate solution | | color | Colorless to light yellow | | InChI | 1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1 | | InChIKey | VHRUMKCAEVRUBK-GODQJPCRSA-N | | SMILES | CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O |
| Hazard Codes | F,Xi | | Risk Statements | 11-36/38-66-67-36 | | Safety Statements | 16-26-29-33-36/37/39 | | RIDADR | UN 1231 3/PG 2 | | WGK Germany | 1 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 2
STOT SE 3 |
| | 15D-PGJ2 Usage And Synthesis |
| Uses | 15-Deoxy-Δ12,14-prostaglandin J2 has been used:
- to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
| | Definition | ChEBI: 15-deoxy-Delta(12,14)-prostaglandin J2 is a prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions. It has a role as a metabolite, an electrophilic reagent and an insulin-sensitizing drug. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 15-deoxy-Delta(12,14)-prostaglandin J2(1-). | | General Description | A metabolite of PGD2 that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding. | | Biological Activity | Selective PPAR γ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC 50 = 7 μ M). | | Biochem/physiol Actions | 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis. |
| | 15D-PGJ2 Preparation Products And Raw materials |
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