8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Suppliers list

Company Name:	Labnetwork lnc.
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Products Intro:	Product Name:tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate CAS:149771-44-8 Purity:95% Package:1g Remarks:LN00008337

Company Name:	Capot Chemical Co.,Ltd.
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Products Intro:	Product Name:8-Boc-3,8-diaza-bicyclo[3.2.1]octane CAS:149771-44-8 Purity:98% Min. Package:1G;1KG;100KG

Company Name:	Shanghai Daken Advanced Materials Co.,Ltd
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Products Intro:	Product Name:8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE CAS:149771-44-8 Purity:99% Package:1KG,5KG,10KG

Company Name:	Shenzhen Nexconn Pharmatechs Ltd
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Products Intro:	Product Name:Tert-Butyl 3,8-Diazabicyclo[3.2.1]Octane-8-Carboxylate CAS:149771-44-8 Purity:98% Package:1KG;10KG;50KG

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Products Intro:	Product Name:8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE CAS:149771-44-8 Purity:98% Package:5KG;1KG

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE manufacturers

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Basic information

Product Name:	8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE
Synonyms:	8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE;8-t-butoxycarbonyl-3,8-diazabicyclo[3.2.1]octane;3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 8-BOC protected 97+%;1,1-Dimethylethyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate;EOS-62177;8-Boc-3,8-diaza-bicyclo[3.2.1]octane hydrochloride;3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 1,1-diMethylethyl ester;3,8-Diazabicyclo[3.2.1]octan-8-carboxylic acid tert-butyl ester
CAS:	149771-44-8
MF:	C11H20N2O2
MW:	212.29
EINECS:
Product Categories:	pharmaceutical;1
Mol File:	149771-44-8.mol

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Chemical Properties

Boiling point	295.4±15.0 °C(Predicted)
density	1.076±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	solid
pka	9.53±0.20(Predicted)
color	White to off-white
InChI	InChI=1S/C11H20N2O2/c1-11(2,3)15-10(14)13-8-4-5-9(13)7-12-6-8/h8-9,12H,4-7H2,1-3H3
InChIKey	HNINFCBLGHCFOJ-UHFFFAOYSA-N
SMILES	C12N(C(OC(C)(C)C)=O)C(CC1)CNC2

Safety Information

HS Code

2933599590

MSDS Information

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Usage And Synthesis

Uses	tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate is used in preparation of isoquinolinone derivatives and pharmaceutical compounds thereof for prevention or treatment of poly(ADP-ribose)polymerase-1 (PARP-1)-associated diseases.
Synthesis	149771-43-7 149771-44-8 The hydrogenation reaction of tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate (13.0 g, 43.0 mmol) was carried out in ethanol (100 mL, 99%) in the presence of palladium carbon (4.0 g, 5%) catalyst. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was dried and the solvent evaporated to afford the white powdery product tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate. The yield was 8.4 g (92% yield) and the melting point was 103.4-106°C. The product was obtained as follows.
References	[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 5, p. 674 - 681 [2] Patent: US2002/128271, 2002, A1 [3] Patent: EP1213289, 2002, A1. Location in patent: Page 13 [4] Patent: WO2006/106090, 2006, A1. Location in patent: Page/Page column 16 [5] Tetrahedron Letters, 2002, vol. 43, # 5, p. 899 - 902

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Preparation Products And Raw materials

Raw materials	3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 3-(2,2,2-trifluoroacetyl)-, 1,1-diMethylethyl ester-->TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE-->Ethanol-->Hydrogen
Preparation Products	TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE-->4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE

Tag:8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE(149771-44-8) Related Product Information

TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate hydrochloride tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate tert-butyl 6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylate 3-AMINO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-PIPERIDINEACETIC ACID METHYL ESTER tert-butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate 1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester TERT-BUTYL N-ALLYLCARBAMATE 1-Boc-3-methyl-3-hydroxyp... 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester N-BOC-3-METHYLENE-PIPERIDINE tert-butyl 3,3a,4,5-tetrahydro-5-oxocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl carbazate tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate (R)-1-N-Boc-2-methylpiperazine (R)-2-(Aminomethyl)-1-N-Boc-pyyrolidine (S)-1-N-Boc-2-(aminomethyl)pyrrolidine

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