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| | 1-BENZYL-HEXAHYDRO-4H-AZEPIN-4-ONE Basic information |
| Product Name: | 1-BENZYL-HEXAHYDRO-4H-AZEPIN-4-ONE | | Synonyms: | 1-BENZYL-HEXAHYDRO-4H-AZEPIN-4-ONE;1-Benzylazepan-4-one;1-Benzylhexahydro-4-azepinone;4H-Azepin-4-one,hexahydro-1-(phenylmethyl)-;N-Benzylazepane-4-one;4H-Azepin-4-one;hexahydro-1-(phenylMethyl)-;1-benzyl-4-azepanone | | CAS: | 1208-75-9 | | MF: | C13H17NO | | MW: | 203.28 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 1208-75-9.mol |  |
| | 1-BENZYL-HEXAHYDRO-4H-AZEPIN-4-ONE Chemical Properties |
| Boiling point | 115-118 °C(Press: 0.01 Torr) | | density | 1.069 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 7.61±0.20(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | 1-BENZYL-HEXAHYDRO-4H-AZEPIN-4-ONE Usage And Synthesis |
| Synthesis | Potassium carbonate (K2CO3, 12 g, 88 mmol, 3.0 eq.) was added to acetone (10 mL) as 4-azepinone hydrochloride (1-18, 4.4 g, 29 mmol) and benzyl bromide (5.0 g, 29 mmol, 1.0 eq.). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the crude reaction mixture was concentrated by evaporation, the residue was dissolved in ethyl acetate and the organic layer was washed with water. The crude product was purified by silica gel column chromatography to afford 1-benzylhexahydroazepin-4-one (1-19, 5.6 g, 95% yield). Mass spectrometric (ESI) analysis showed m/z 204.1 (M + H+). | | References | [1] Patent: WO2010/144571, 2010, A1. Location in patent: Page/Page column 133-134
[2] Patent: WO2015/140559, 2015, A1. Location in patent: Page/Page column 50; 51
[3] Patent: US2013/143870, 2013, A1. Location in patent: Paragraph 0489; 0490
[4] Patent: US2013/150341, 2013, A1. Location in patent: Paragraph 0418; 0419
[5] Patent: WO2013/83741, 2013, A1. Location in patent: Page/Page column 98 |
| | 1-BENZYL-HEXAHYDRO-4H-AZEPIN-4-ONE Preparation Products And Raw materials |
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