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SynAsst Chemical.
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Product Name:3,4-Dihydroquinazolin-2(1H)-one
CAS:66655-67-2
Purity:96%Min Package:10g 100g 500g
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| | 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Basic information |
| Product Name: | 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE | | Synonyms: | 3,4-DIHYDRO-1H-QUINAZOLIN-2-ONE;3,4-Dihydro-2(1H)-quinazolinone;3,4-DIHYDROQUINAZOLIN-2(1H)-ONE;1,2,3,4-tetrahydroquinazolin-2-one;3,4-Dihydro-1H-quizolin-2-one;2(1H)-Quinazolinone, 3,4-dihydro- | | CAS: | 66655-67-2 | | MF: | C8H8N2O | | MW: | 148.16 | | EINECS: | | | Product Categories: | aniline | | Mol File: | 66655-67-2.mol |  |
| | 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Chemical Properties |
| Melting point | 241-242℃ | | Boiling point | 257℃ | | density | 1.19 | | Fp | 120℃ | | storage temp. | Sealed in dry,Room Temperature | | pka | 12+-.0.20(Predicted) |
| | 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3,4-dihydro-1H-quinazolin-2-one from 2-aminobenzylamine and molybdenum hexacarbonyl was as follows: the reaction was carried out in a two-chamber system. First, 2-aminobenzylamine, Pd(OAc)2 (0.05 eq.) and Cu(OAc)2 (0.5 eq.) were added to the reaction chamber and dissolved in 1,4-dioxane (2 mL). In a CO chamber, Mo(CO)6 (200 mg) was dissolved in 1,4-dioxane (2 mL). Subsequently, 1,8-diazabicyclo[5.4.0]undec-7-ene was added to the system. The two-compartment system was placed in a Dry-Syn heating block and heated to 95°C for the reaction. Upon completion of the reaction, the reaction mixture was filtered through a short silica gel plug and subsequently purified by fast column chromatography. | | References | [1] Molecules, 2017, vol. 22, # 10, |
| | 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Preparation Products And Raw materials |
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