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| | Hemopressin (human, bovine, porcine) Basic information |
| Product Name: | Hemopressin (human, bovine, porcine) | | Synonyms: | Hemopressin (human, bovine, porcine);H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH;L-Histidine, L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl- | | CAS: | 1314035-51-2 | | MF: | C50H79N13O12 | | MW: | 1054.24 | | EINECS: | | | Product Categories: | | | Mol File: | 1314035-51-2.mol |  |
| | Hemopressin (human, bovine, porcine) Chemical Properties |
| Boiling point | 1491.3±65.0 °C(Predicted) | | density | 1.258±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 2.77±0.10(Predicted) | | form | Powder | | color | White to off-white | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH |
| | Hemopressin (human, bovine, porcine) Usage And Synthesis |
| Uses | Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models[1][2]. | | in vivo | Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE)[1].
Oral administration of Hemopressin inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats[2].
| | storage | Store at -20°C | | References | [1] Garron T Dodd, et al. The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J Neurosci. 2010 May 26;30(21):7369-76. DOI:10.1523/JNEUROSCI.5455-09.2010
[2] Elaine F Toniolo, et al. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides. 2014 Jun;56:125-31. DOI:10.1016/j.peptides.2014.03.016 |
| | Hemopressin (human, bovine, porcine) Preparation Products And Raw materials |
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