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| | 1-Methyl-3-azetidinecarboxylic acid Basic information |
| Product Name: | 1-Methyl-3-azetidinecarboxylic acid | | Synonyms: | 1-Methyl-3-azetidinecarboxylic acid;1-Methyl-3-azetidinecarbo...;3-Carboxy-1-methylazetidine, 3-Carboxy-1-methylazetane;3-Azetidinecarboxylic acid, 1-methyl-;1-Methylazetidine-3-carboxylic acid - [M0190];1-Methylazetidine-3-carboxylic acid | | CAS: | 875629-26-8 | | MF: | C5H9NO2 | | MW: | 115.13 | | EINECS: | | | Product Categories: | | | Mol File: | 875629-26-8.mol |  |
| | 1-Methyl-3-azetidinecarboxylic acid Chemical Properties |
| Boiling point | 208.3±33.0 °C(Predicted) | | density | 1+-.0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 2.41±0.20(Predicted) | | form | powder | | color | White |
| Hazard Codes | Xn | | Risk Statements | 22 | | HS Code | 2933998090 |
| | 1-Methyl-3-azetidinecarboxylic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 1-methyl-3-azetidinecarboxylic acid from formaldehyde and 3-acridinecarboxylic acid:
Example IX Synthesis of 1-methyl-azetidine-3-carboxylic acid
200 mg of azetidine-3-carboxylic acid was dissolved in 10 mL of methanol and 165 μL of 37% aqueous formaldehyde solution and 20 mg of 10% palladium carbon catalyst were added. The reaction mixture was hydrogenated at 50 °C. Upon completion of the reaction, the catalyst was removed by filtration followed by evaporation under vacuum to remove the solvent. The residue was redissolved in a solvent mixture of methanol and toluene and the solvent was again removed by evaporation under vacuum. The final product yield was 214 mg (94% yield, based on theoretical calculations). The product was analyzed by mass spectrometry (ESI+) and showed m/z = 116 [M + H]+. | | References | [1] Patent: US2011/269737, 2011, A1. Location in patent: Page/Page column 44 |
| | 1-Methyl-3-azetidinecarboxylic acid Preparation Products And Raw materials |
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