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| | Amodiaquine-d10 Basic information |
| | Amodiaquine-d10 Chemical Properties |
| Melting point | 194-198°C | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | Pale Yellow to Light Yellow |
| | Amodiaquine-d10 Usage And Synthesis |
| Description | Amodiaquine-d10 is intended for use as an internal standard for the quantification of amodiaquine by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine . It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine. Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection. | | Chemical Properties | Pale Yellow Solid | | Uses | An antimalarial. | | IC 50 | Plasmodium | | References | [1] S T MARIGA. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro.[J]. Antimicrobial Agents and Chemotherapy, 2004, 48 11: 4089-4096. DOI: 10.1128/aac.48.11.4089-4096.2004
[2] JULIANA M Sá T E W Jason L Chong. Malaria drug resistance: new observations and developments.[J]. Essays in biochemistry, 2011, 51: 137-160. DOI: 10.1042/bse0510137
[3] R. JACOBS W C D Alling. AN EVALUATION OF ANTIMALARIAL COMBINATIONS AGAINST PLASMODIUM BERGHEI IN THE MOUSE.[J]. Kisaengch’unghak chapchi. The Korean journal of parasitology, 1963, 11 1: 920-925. DOI: 10.2307/3275719 |
| | Amodiaquine-d10 Preparation Products And Raw materials |
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