rac trans-4-Hydroxy Glyburide
| 中文名称 | rac trans-4-Hydroxy Glyburide |
|---|---|
| 中文同义词 | |
| 英文名称 | rac trans-4-Hydroxy Glyburide |
| 英文同义词 | 4-trans-Hydroxycyclohexyl Glyburide;5-Chloro-N-[2-[4-[[[[(trans-4-hydroxycyclohexyl)aMino]carbonyl]aMino]sulfonyl]phenyl]ethyl]-2-MethoxybenzaMide;N-[4-[β-(2-Methoxy-5-chlorobenzaMido)ethyl] benzenesulfonyl]-N'-(trans-4-hydroxycyclohexyl)urea;trans-1-[[p-[2-(5-Chloro-o-anisaMido)ethyl]phenyl] sulfonyl]-3-(4-hydroxycyclohexyl)urea;trans-4-Hydroxyglyburide;Glyburide trans-4-Hydroxycyclohexyl;Glibenclamide trans-4-Hydroxycyclohexyl;Benzamide, 5-chloro-N-[2-[4-[[[[(trans-4-hydroxycyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy- |
| CAS号 | 23155-00-2 |
| 分子式 | C23H28ClN3O6S |
| 分子量 | 510 |
| EINECS号 | |
| 相关类别 | Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds |
| Mol文件 | 23155-00-2.mol |
| 结构式 |  |
rac trans-4-Hydroxy Glyburide 性质
| 熔点 | 184-186 °C(Solvent: Ethanol) |
|---|---|
| 密度 | 1.414±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 储存条件 | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| 溶解度 | DMSO：微溶，甲醇：微溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.170±0.10(predicted) |
| 稳定性 | 吸湿性和对水分敏感 |
rac-trans-4-hydroxy Glyburide 是 SUR1/Kir6.2 磺酰脲类抑制剂格列苯脲 (HY-15206) 的活性代谢物。它由格列苯脲经细胞色素 P450 (CYP) 同工酶 CYP2C8 和 CYP2C9 作用而形成。rac-trans-4-hydroxy Glyburide 可抑制格列苯脲与大鼠脑突触体在 SUR1/Kir6.2 高亲和力位点和低亲和力位点的结合，IC50 值分别为 0.95 和 100 nM。