| Company Name: |
Shanghai potentpharm CO.,Ltd
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| Tel: |
13524892556 |
| Email: |
sales-cn@potentpharm.com |
| Products Intro: |
Product Name:8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
CAS:98232-51-0
Purity:97% Package:1g;5g;25g;100g;500g;1kg
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| Company Name: |
LABTER PHARMATECH(BEIJING) CO.,LTD
|
| Tel: |
010-56330744 18310155299 |
| Email: |
sales@labter.com.cn |
| Products Intro: |
Product Name:8-METHOXY-3,4-DIHYDROBENZO[B]OXEPIN-5(2H)-ONE
CAS:98232-51-0
Purity:95% HPLC Package:1g;5g;10g;25g;100g
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| Company Name: |
Biokitchen
|
| Tel: |
021-021-021-31663258 13795219287 |
| Email: |
donghuanwen@126.com |
| Products Intro: |
Product Name:8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one
CAS:98232-51-0
Purity:> 97% HPLC Package:10G;100G；500G；1KG; 5KG, 10KG; 100KG
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| | 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one Basic information |
| | 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one Chemical Properties |
| Boiling point | 140 °C(Press: 0.6 Torr) | | density | 1.161±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | Appearance | Yellow to brown Liquid |
| | 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one from 3-methoxyphenoxybutyric acid: a chlorobenzene solution of polyphosphoric acid (PPA) was slowly added to compound Int-19d (22 g, 0.1 mol) at 80 °C and the reaction mixture was kept stirred continuously at 80 °C for about 15 hours. After completion of the reaction, the solvent was removed and the residue was dissolved in ethyl acetate and washed sequentially with 1N aqueous sodium hydroxide and saturated saline. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target compound Int-19e (14 g, 73% yield). The product was characterized by 1H NMR (CDCl3) with chemical shifts δ: 7.74 (d, J = 8Hz, 1H), 6.63 (d, J = 8Hz, 1H), 6.53 (s, 1H), 4.21 (t, J = 12Hz, 2H), 3.80 (s, 3H), 2.84 (t, J = 16Hz, 2H), 2.18-2.15 (m, 2H ). | | References | [1] Patent: WO2012/50848, 2012, A1. Location in patent: Page/Page column 109-110
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 23, p. 5025 - 5033
[3] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 21, p. 9554 - 9573
[4] Justus Liebigs Annalen der Chemie, 1954, vol. 587, p. 38,47
[5] Synthetic Communications, 2009, vol. 39, # 15, p. 2664 - 2673 |
| | 8-methoxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one Preparation Products And Raw materials |
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