- 4-Hydroxyindazole
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- $1.00
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2020-01-10
- CAS:81382-45-8
- Min. Order: 1g
- Purity: 95--99%
- Supply Ability: 1ton
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| | 4-HYDROXYINDAZOLE Basic information | | Uses |
| Product Name: | 4-HYDROXYINDAZOLE | | Synonyms: | 4-HYDROXYINDAZOLE;4-Hydroxyindazole HCl;4-HYDROXYL (1H)INDAZOLE;1H-Indazol-4-ol ,97%;4-Hydroxy-1H-indazole;4-Hydroxyindazole hydrochloride;1,2-dihydroindazol-4-one hydrochloride;1H-Indazol-4-ol | | CAS: | 81382-45-8 | | MF: | C7H6N2O | | MW: | 134.14 | | EINECS: | 200-258-5 | | Product Categories: | pharmacetical | | Mol File: | 81382-45-8.mol |  |
| | 4-HYDROXYINDAZOLE Chemical Properties |
| Melting point | 177-178℃ | | Boiling point | 366.5±15.0 °C(Predicted) | | density | 1.434±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 8.76±0.40(Predicted) | | Appearance | Light yellow to green yellow Solid |
| | 4-HYDROXYINDAZOLE Usage And Synthesis |
| Uses | 4-Hydroxyinazole is a heterocyclic compound mainly used in laboratory organic synthesis and chemical production processes. | | Chemical Properties | White to off-white solid | | Synthesis | C. General procedure for the preparation of 4-hydroxyindazole from 4-aminoindazole: 4-aminoindazole (9.6 g, 0.072 mol) was dissolved in a glass reaction vessel containing 7.2 g of concentrated sulfuric acid in 75 mL of water. The mixture was transferred to a stainless steel autoclave, sealed and heated to 170°C for overnight reaction. Upon completion of the reaction, a large amount of black precipitate appeared in the reaction mixture. The reaction mixture was diluted with ethyl acetate and water and transferred to a dispensing funnel for distribution. The aqueous layer was extracted with ethyl acetate several times until 4-hydroxyindazole was completely transferred to the organic phase. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give a dark brown or black oil. The crude product was purified by silica gel column chromatography with an eluent of 50% ethyl acetate/hexane mixture to give 4-hydroxyindazole as an off-white solid (3.3 g, 33% yield). | | References | [1] Patent: WO2004/39796, 2004, A1. Location in patent: Page/Page column 71-72
[2] Patent: US6534504, 2003, B1
[3] Patent: US6841563, 2005, B1. Location in patent: Page column 20
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 8, p. 3975 - 3991
[5] Journal of the Chemical Society, 1955, p. 2412,2419 |
| | 4-HYDROXYINDAZOLE Preparation Products And Raw materials |
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