| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
|
| | CAY10607 Basic information |
| Product Name: | CAY10607 | | Synonyms: | CAY10607;Benzisoxazole Hsp90 Inhibitor;CAY10607 Exclusive;1,3-Benzenediol, 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-;HSP90-IN-29 | | CAS: | 1012788-65-6 | | MF: | C19H20ClN3O4 | | MW: | 389.83 | | EINECS: | | | Product Categories: | | | Mol File: | 1012788-65-6.mol |  |
| | CAY10607 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml | | form | A crystalline solid |
| | CAY10607 Usage And Synthesis |
| Description | Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay). It is selective for Hsp90 over a panel of kinases (IC50s = >20 μM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 μM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 μM for both. | | Uses | Benzisoxazole Hsp90 Inhibitor is an inhibitor that binds to the N-terminal domain of Hsp90. | | Definition | ChEBI: 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol is a member of the class of 1,2-benzoxazoles carrying 2,4-dihydroxy-4-chlorophenyl and (2-morpholin-4-ylethyl)amino substituents at positions 3 and 5 respectively. It has a role as a Hsp90 inhibitor. It is a member of 1,2-benzoxazoles, a member of morpholines, a member of resorcinols, a member of monochlorobenzenes, a tertiary amino compound, a secondary amino compound and an aromatic amine. | | IC 50 | HSP90: 30 nM (IC50) | | References | [1] ARIAMALA GOPALSAMY*. Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90[J]. Journal of Medicinal Chemistry, 2008, 51 3: 373-375. DOI: 10.1021/jm701385c |
| | CAY10607 Preparation Products And Raw materials |
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