D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

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D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) Basic information
Product Name:D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
Synonyms:D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt);D-myo-Inositol 1,4,5,6-tetrakis(dihydrogen phosphate) tetrasodium salt;D-myo-Inositol-1,4,5,6-tetraphosphate (sodium)
CAS:157542-47-7
MF:C6H17NaO18P4
MW:524.07
EINECS:
Product Categories:
Mol File:157542-47-7.mol
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) Structure
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) Chemical Properties
storage temp. Store at -20°C
form A lyophilized powder
Water Solubility 50mg/mL in water
Safety Information
MSDS Information
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) Usage And Synthesis
DescriptionD-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.1 Ins(1,4,5,6)-P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway.1 Ins(1,4,5,6)-P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.2
UsesD-myo-Inositol-1,4,5,6-tetraphosphate sodium is one of several different inositol oligophosphate isomers implicated in signal transduction[1].
References1. Eckmann, L., Rudolf, M.T., Ptasznik, A., et al. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways Proc. Natl. Acad. Sci. USA 94,14456-14460(1997).
2. DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates Am. J. Physiol. 266(2 Pt 1),C429-C436(1994).
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) Preparation Products And Raw materials
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