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| | HDAC5 (human recombinant) Basic information |
| | HDAC5 (human recombinant) Chemical Properties |
| | HDAC5 (human recombinant) Usage And Synthesis |
| Description | Histone deacetylases (HDACs) catalyze the deacetylation of core histones, resulting in tightening of nucleosomal integrity, restriction of the access of transcription factors, and suppression of transcription. HDACs also play an important role in mediating nuclear receptor functions by forming co-repressor complexes with nuclear receptors in the absence of ligands. They are also involved in mediating other transcription regulatory pathways by associating with transcription factors, such as E2F, TFIIE, TFIIF, NF-κB, p300, Stat3, p53, and the retinoblastoma (Rb) protein. HDAC5 is a Class IIa HDAC which is homologous to yeast Hda 1 and is larger in size than the other two classes of HDACs. Class IIa HDACs contain a highly conserved C-terminal deacetylase catalytic domain (~420 amino acids) and an N-terminal domain with no similarity to HDACs in other classes. Class IIa HDACs can shuttle between the nucleus and cytoplasm, suggesting potential extranuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases. | | References | [1] T A MCKINSEY E N O C L Zhang. Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.[J]. Molecular and Cellular Biology, 2001, 21 1: 6312-6321. DOI: 10.1128/mcb.21.18.6312-6321.2001
[2] C M GROZINGER S L S. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 14: 7835-7840. DOI: 10.1073/pnas.140199597
[3] ANNEMIEKE J M DE RUIJTER. Histone deacetylases (HDACs): characterization of the classical HDAC family.[J]. Biochemical Journal, 2003, 370 Pt 3: 737-749. DOI: 10.1042/bj20021321
[4] SHURONG CHANG. Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development.[J]. Molecular and Cellular Biology, 2004, 24 19: 8467-8476. DOI: 10.1128/mcb.24.19.8467-8476.2004
[5] ROBERTO CARLOS AGIS-BALBOA. Loss of HDAC5 impairs memory function: implications for Alzheimer’s disease.[J]. Journal of Alzheimer’s Disease, 2013, 33 1: 35-44. DOI: 10.3233/jad-2012-121009
[6] JUN YANG. Insights Into the Function and Clinical Application of HDAC5 in Cancer Management.[J]. Frontiers in Oncology, 2021: 661620. DOI: 10.3389/fonc.2021.661620 |
| | HDAC5 (human recombinant) Preparation Products And Raw materials |
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