| Company Name: |
JW & Y Pharmlab Co., Ltd. Gold
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| Tel: |
021-64340559 13651849907 |
| Email: |
xinyu_shi@jwypharmlab.com.cn |
| Products Intro: |
Product Name:3-(Toluene-4-sulfonyl)-3-aza-bicyclo[3.2.0]heptan-6-one
CAS:122080-99-3
Purity:0.96 Package:1g;5g;25g;100g;250g等可分装
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| | 3-(4-Methylbenzenesulfonyl)-3-
azabicyclo[3.2.0]heptan-6-one Basic information |
| Product Name: | 3-(4-Methylbenzenesulfonyl)-3-
azabicyclo[3.2.0]heptan-6-one | | Synonyms: | 3-(4-Methylbenzenesulfonyl)-3-
azabicyclo[3.2.0]heptan-6-one;3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one;3-(Toluene-4-sulfonyl)-3-aza-bicyclo[3.2.0]heptan-6-one;Cis-3-Tosyl-3-Azabicyclo[3.2.0]Heptan-6-One;3-(4-methylphenyl)sulfonyl-3-azabicyclo[3.2.0]heptan-6-one;3-Azabicyclo[3.2.0]heptan-6-one, 3-[(4-methylphenyl)sulfonyl]- | | CAS: | 122080-99-3 | | MF: | C13H15NO3S | | MW: | 265.33 | | EINECS: | | | Product Categories: | | | Mol File: | 122080-99-3.mol | ![3-(4-Methylbenzenesulfonyl)-3-
azabicyclo[3.2.0]heptan-6-one Structure](CAS/GIF/122080-99-3.gif) |
| | 3-(4-Methylbenzenesulfonyl)-3-
azabicyclo[3.2.0]heptan-6-one Chemical Properties |
| Boiling point | 437.5±55.0 °C(Predicted) | | density | 1.351±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | -5.91±0.20(Predicted) |
| | 3-(4-Methylbenzenesulfonyl)-3-
azabicyclo[3.2.0]heptan-6-one Usage And Synthesis |
| Synthesis | A 1,2-dichloroethane (250 mL) solution of Compound 6 (35 g, 0.10 mol) was slowly added dropwise over 20 minutes to a 1,2-dichloroethane (100 mL) solution of trifluoromethanesulfonic anhydride (58 g, 0.20 mol). Subsequently, a 1,2-dichloroethane (100 mL) solution of colistin (19 g, 0.15 mol) was added slowly over 30 minutes. The reaction mixture was heated to 90 °C and stirred for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated. The residue was hydrolyzed in the two-phase system H2O-CCl4. The organic layer was separated, dried with anhydrous Na2SO4, filtered and the filtrate evaporated to remove the solvent. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10/1) to afford compound 7 (15 g, 54% yield) as a white solid.1H NMR (400 MHz, CDCl3): δ 2.45 (s, 3H), 2.67-2.72 (m, 1H), 2.85-2.92 (m, 1H), 2.94-3.00 (m, 2H), 3.27-3.35 (m, 1H), 3.59-3.66 (m, 2H), 3.17-3.12 (m, 2H), 3.83-3.86 (d, J=10Hz, 1H), 7.34-7.36 (d, J=8Hz, 2H), 7.69-7.71 (d, J=8.4Hz, 2H); MS calculated values: 265; MS measured value: 266 ([M+H]+). | | References | [1] Patent: WO2015/38661, 2015, A1. Location in patent: Paragraph 0139 |
| | 3-(4-Methylbenzenesulfonyl)-3-
azabicyclo[3.2.0]heptan-6-one Preparation Products And Raw materials |
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