- 2-ACETYLTHIOPHENE
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- $1.00 / 1PCS
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2026-03-20
- CAS:88-15-3
- Min. Order: 1PCS
- Purity: 99%
- Supply Ability: 10 mt
- 2-Acetylthiophene
-
- $0.00 / 1kg
-
2025-11-20
- CAS:88-15-3
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 100tons
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| | 2-Acetylthiophene Chemical Properties |
| Melting point | 10-11 °C (lit.) | | Boiling point | 214 °C (lit.) | | density | 1.168 g/mL at 25 °C (lit.) | | vapor pressure | 2.7 hPa (50 °C) | | refractive index | n20/D 1.565(lit.) | | Fp | 196 °F | | storage temp. | Store below +30°C. | | solubility | 14g/l | | form | Liquid | | color | Clear pale yellow to light brown | | Odor | at 100.00 %. sulfurous nutty hazelnut walnut | | Odor Type | sulfurous | | biological source | synthetic | | Water Solubility | Insoluble in water. | | Sensitive | Light Sensitive | | BRN | 107910 | | Major Application | flavors and fragrances | | InChI | 1S/C6H6OS/c1-5(7)6-3-2-4-8-6/h2-4H,1H3 | | InChIKey | WYJOVVXUZNRJQY-UHFFFAOYSA-N | | SMILES | CC(=O)c1cccs1 | | LogP | 1.250 | | CAS DataBase Reference | 88-15-3(CAS DataBase Reference) | | NIST Chemistry Reference | Ethanone, 1-(2-thienyl)-(88-15-3) | | EPA Substance Registry System | Ethanone, 1-(2-thienyl)- (88-15-3) |
| Hazard Codes | T,Xi,Xn | | Risk Statements | 25-23/24/25-20/21/22 | | Safety Statements | 45-38-36/37/39-28-36 | | RIDADR | UN 2810 6.1/PG 2 | | WGK Germany | 3 | | RTECS | OB6300000 | | F | 13 | | Autoignition Temperature | 265 °C DIN 51794 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29349990 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Inhalation
Acute Tox. 2 Oral
Acute Tox. 3 Dermal | | Toxicity | LD50 orally in Rabbit: 25 - 200 mg/kg LD50 dermal Rat 370 mg/kg |
| | 2-Acetylthiophene Usage And Synthesis |
| Description | 2-Acetylthiophene occurs naturally in kohlrabi. It has a sulfurous nutty hazelnut odor. It can be used as a food additive. It is also used as an intermediate to produce drugs, such as Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc.
| | Chemical Properties | clear colorless to slightly yellow liquid | | Uses | 2-Acetylthiophene(2AT) is used as an intermediate in the manufacturing of drugs like Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc. 2AT is used as an important precursor to thiophene-2-acetic acid (T2AA) or its acid chloride (Cl) and thiophene-2-carboxylic acid (T2CA) (Cl). It is important that the process used to synthesize 2AT yields the lowest amount of 3- acetylthiophene isomer. | | Definition | ChEBI: 2-Acetylthiophene is an aromatic ketone. | | Synthesis Reference(s) | Organic Syntheses, Coll. Vol. 2, p. 8, 1943
The Journal of Organic Chemistry, 36, p. 540, 1971 DOI: 10.1021/jo00803a011
Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1 | | Safety Profile | Poison by intraperitoneal route. A flammable liquid. When heated to decomposition emits toxic fumes of SOx,. | | Solubility in organics |
2-Acetylthiophene is miscible at 25°C with triethylene glycol, methanol, ethanol, n-butanol, diethyl ether, dioxane, cellulose butyl ester, ethyl acetate, acetone, acetonitrile, carbon disulphide, carbon tetrachloride, nitromethane, acetic acid, thiophene, tetranaphthalene, aminobenzene, and benzene . It is immiscible with water, glycerol, ethylene glycol, decahydronaphthalene, cyclohexane, diisobutylene, 1-hexadecene, and n-heptane. When equal volumes are mixed, 2-acetylthiophene is miscible with n-heptane above 60.8°C and with ethylene glycol above 31.1°C.
[1] JOHNSON G C. Physical Properties of 2-Acetylthiophene[J]. Journal of the American Chemical Society, 1947, 69 1: 150-152. DOI:10.1021/ja01193a040.
| | Purification Methods | Fractionally distil the thiophene through a 12-plate column, and fraction b 77o/4mm is collected. Also wet the acetylthiophene in order to remove and free thiophene which forms an azeotrope with H2O, b 68o. Store it in a brown bottle, and the clear colourless liquid remains thus for extended periods. [Kosak & Hartough Org Synth Coll Vol III 14 1955, Hartough & Kosak J Am Chem Soc 69 3093 1947.] The red 4-nitrophenylhydrazone crystallises from EtOH with m 181-182o. [Beilstein 17/9 V 387.] |
| | 2-Acetylthiophene Preparation Products And Raw materials |
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