|
|
| | 3-Hydroxy-3-methylpyrrolidine hydrochloride Basic information |
| | 3-Hydroxy-3-methylpyrrolidine hydrochloride Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | Orange to Very Dark Brown | | Stability: | Hygroscopic |
| | 3-Hydroxy-3-methylpyrrolidine hydrochloride Usage And Synthesis |
| Uses | 3-Methylpyrrolidin-3-ol Hydrochloride can be used to treat inflammatory disorders. | | Synthesis | The general procedure for the synthesis of 3-hydroxy-3-methylpyrrolidine-1-carboxylic acid tert-butyl ester from 3-hydroxy-3-methylpyrrolidine-1-carboxylic acid is as follows: tert-butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylic acid tert-butyl ester (0.027 g, 0.13 mmol) was added to a solution of 4N HCl/dioxane (1 ml), and the reaction mixture was stirred for 2 hours at room temperature. After completion of the reaction, the solution was concentrated under reduced pressure to remove the solvent. The concentrated residue was diluted with toluene (1 ml) and concentrated again under reduced pressure to finally obtain 3-hydroxy-3-methylpyrrolidine hydrochloride as a colorless oil (0.018 g, 100% yield). | | References | [1] Patent: WO2008/24725, 2008, A1. Location in patent: Page/Page column 124
[2] Patent: EP2703398, 2014, A1. Location in patent: Paragraph 0121; 0122
[3] Patent: EP2703398, 2014, A1. Location in patent: Paragraph 0175; 0176
[4] Patent: WO2016/100940, 2016, A1. Location in patent: Page/Page column 156
[5] Patent: WO2007/11284, 2007, A1. Location in patent: Page/Page column 29 |
| | 3-Hydroxy-3-methylpyrrolidine hydrochloride Preparation Products And Raw materials |
|