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6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine

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6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine manufacturers

  • Dipraglurant
  • Dipraglurant pictures
  • $98.00 / 1mg
  • 2026-04-21
  • CAS:872363-17-2
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  • Purity: 98.70%
  • Supply Ability: 10g
  • Dipraglurant
  • Dipraglurant pictures
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:872363-17-2
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Dipraglurant
  • Dipraglurant pictures
  • $15.00 / 1KG
  • 2021-07-10
  • CAS:872363-17-2
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine Basic information
Product Name:6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine
Synonyms:6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine;Dipraglurant;ADX 48621;ADX48621;6-fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]-Imidazo[1,2-a]pyridine;Icosabutate;Imidazo[1,2-a]pyridine, 6-fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]-
CAS:872363-17-2
MF:C16H12FN3
MW:265.29
EINECS:
Product Categories:
Mol File:872363-17-2.mol
6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine Structure
6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine Chemical Properties
density 1.16
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka5.59±0.50(Predicted)
color White to off-white
Safety Information
MSDS Information
6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine Usage And Synthesis
UsesDipraglurant (ADX48621) is a potent, selective, orally active and brain penetrant mGluR5 negative allosteric modulator (NAM), with an IC50 of 21 nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo[1][2]. Dipraglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo

Dipraglurant (3-30 mg/kg; a single p.o.) reduces L-dopa-induced chorea and dystonia and does not interfere with the efcacy of L-dopa in treating parkinsonian disability macaque[1].
Dipraglurant exhibits Cmax (1.040, 1.380, 5.310 ng/mL) Tmax (1.0, 0.5, 1.0 h) and AUCinf (2.230, 2.860, 15.700) following p.o. administration (3, 10, 30 mg/kg) in macaque[1].

IC 50mGluR5: 21 nM (IC50)
References[1] The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12
[2] Bezard E, et, al. The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model. Mov Disord. 2014 Jul;29(8):1074-9. DOI:10.1002/mds.25920
[3] Sciamanna G, et, al. Negative allosteric modulation of mGlu5 receptor rescues striatal D2 dopamine receptor dysfunction in rodent models of DYT1 dystonia. Neuropharmacology. 2014 Oct;85:440-50. DOI:10.1016/j.neuropharm.2014.06.013
6-Fluoro-2-[4-(pyridin-2-yl)-3-butynyl]imidazo[1,2-a]pyridine Preparation Products And Raw materials
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