- KGN，Kartogenin
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- $1.00
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2026-06-27
- CAS:4727-31-5
- Min. Order: 1bag
- Purity: ＞98%
- Supply Ability: 100g
- Kartogenin
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- $46.00
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2026-06-16
- CAS:4727-31-5
- Purity: 98.00%
- Supply Ability: 10g
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| Product Name: | KGN | | Synonyms: | 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid;2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid;4'-Phenylphthalanilic Acid;KGN;4′-Phenyl-phthalanilic acid (8CI);n-Biphenyl-4-yl-phthalamic acid;100822;CS-612 | | CAS: | 4727-31-5 | | MF: | C20H15NO3 | | MW: | 317.34 | | EINECS: | | | Product Categories: | Inhibitors;API | | Mol File: | 4727-31-5.mol |  |
| Melting point | 272 °C | | Boiling point | 464.4±38.0 °C(Predicted) | | density | 1.289±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: >15mg/mL | | form | powder | | pka | 3.45±0.36(Predicted) | | color | White | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | InChI | 1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24) | | InChIKey | SLUINPGXGFUMLL-UHFFFAOYSA-N | | SMILES | O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O |
| Hazard Codes | Xn,N | | Risk Statements | 22-36-50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | HS Code | 2916310090 | | Storage Class | 11 - Combustible Solids |
| Description | Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro. | | Uses | Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed. | | Biochem/physiol Actions | Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ. | | in vivo | Kartogenin (10 μM in 4 μL of saline; i.a. on days 7 and 21) promotes cartilag erepair in collagenase VII-induced OA models in mice[1]. | | storage | +4°C | | References | [1] KRISTEN JOHNSON. A Stem Cell–Based Approach to Cartilage Repair[J]. Science, 2012, 336 6082. DOI:10.1126/science.1215157 |
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