ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >HDAC inhibitors >PCI 34051

PCI 34051

Request For Quotation
PCI 34051 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:PCI 34051
CAS:950762-95-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:PCI-34051
CAS:950762-95-5
Purity:98% HPLC LCMS Package:10G;20G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name: N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
CAS:950762-95-5
Purity:Min98% HPLC Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:PCI-34051
CAS:950762-95-5
Purity:99.14% Package:5mg;55USD|10mg;97USD|25mg;195USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471;
Email: sales@sarms4muscle.com
Products Intro: Product Name:PCI-34051
CAS:950762-95-5
Purity:99% Package:5KG;1KG Remarks:PCI-34051

PCI 34051 manufacturers

  • PCI-34051
  • PCI-34051 pictures
  • $55.00 / 5mg
  • 2026-04-22
  • CAS:950762-95-5
  • Min. Order:
  • Purity: 97.21%
  • Supply Ability: 10g
PCI 34051 Basic information
Product Name:PCI 34051
Synonyms:N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;PCI 34051;PCI-34051;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;PCI-34051;PCI 34051;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide
CAS:950762-95-5
MF:C17H16N2O3
MW:296.32
EINECS:
Product Categories:Apoptosis;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitor
Mol File:950762-95-5.mol
PCI 34051 Structure
PCI 34051 Chemical Properties
density 1.25
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO
pka9.16±0.30(Predicted)
form Powder
color White to gray
InChIInChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20)
InChIKeyAJRGHIGYPXNABY-UHFFFAOYSA-N
SMILESN1(CC2=CC=C(OC)C=C2)C2=C(C=CC(C(NO)=O)=C2)C=C1
Safety Information
Hazard Codes Xn
Risk Statements 22-36
Safety Statements 26
MSDS Information
PCI 34051 Usage And Synthesis
UsesPCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.
DefinitionChEBI: N-hydroxy-1-[(4-methoxyphenyl)methyl]-6-indolecarboxamide is an indolecarboxamide.
Biological Activitypci-34051 is a potent, specific inhibitor of histone deacetylase 8 (hdac8) with greater than 200-fold selectivity over the other hdac isoforms, such as 1, 2, 3, 6 and 10. it induces caspase dependent apoptosis in cell lines derived from t-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines. pci-34051 does not cause detectable histone or tubulin acetylation and also does not inhibit growth or induce apoptosis in normal cells such as pbmcs or fibroblasts. although a phospholipase c-gamma1 (plcgamma1) defective line is resistant, cells defective in t-cell receptor signaling are still sensitive to pci-34051 induced apoptosis.
in vivo

Administration of PCI-34051 and Dexamethasone reduces the eosinophilic inflammation and airway hyperresponsiveness in asthma to reduce the airway remodeling[2].

IC 50HDAC8: 10 nM (IC50); HDAC6: 2.9 μM (IC50); HDAC1: 4 μM (IC50); HDAC10: 13 μM (IC50)
storage-20°C
PCI 34051 Preparation Products And Raw materials
Tag:PCI 34051(950762-95-5) Related Product Information
Ibrutinib N-Ethylaniline 5-METHYL-N,N-DIMETHYLTRYPTAMINE N-Isopropylbenzylamine Tacedinaline JNJ-26481585 Mocetinostat (MGCD0103) Tubastatin-A Entinostat RGFP966